Long-lasting modifications in synaptic efficacy that act in parallel with NMDAR-dependent long-term potentiation
Ahn, "Activation of presynaptic camp-dependent protein kinase is required for induction of cerebellar long-term potentiation
," Journal of Neuroscience, vol.
Hebbian induction of long-term potentiation
of Aplysia sensorimotor synapses: partial requirement for activation of a NMDA-related receptor.
Abbreviations: APV, 2-amino-5-phosphonovalerate; CGC, cerebral giant cells in Lymnaea (MCC homolog); ER, endoplasmic reticulum; LTP, long-term potentiation
; LYC, light yellow cells; MCC, metacerebral cells in Aplysia; NMDA, N-methyl-D-aspartate; NMDAR, ionotropic NMDA-type glutamate receptor; PDZ, acronym from the postsynaptic density 95 (PSD-95), the Drosophila septate junction protein Discs-large and the epithelial tight junction protein ZO-1.
Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation
in the hippocampal CA1 region.
These mice also show altered synaptic plasticity, including a threshold shift in the induction of long-term potentiation
in the dentate gyrus.
Stimulation in hippocampal region CA1 in behaving rats yields long-term potentiation
when delivered to the peak of theta and long-term depression when delivered to the trough.
Impairment of long-term potentiation
and spatial memory in leptin receptor-deficient rodents.
facilitates synaptic strength and may play important roles in hippocampal-dependent spatial learning and memory processes.
In addition, there was significant improvement in synaptic functions, as determined by long-term potentiation
and contextual fear conditioning experiments, in association with the reversal of amyloid plaques.
(LTP) is a form of synaptic plasticity that is an underlying element in the formation and maintenance of a wide range of memory processes [39, 139, 140].
Rusakov, "Long-term potentiation
depends on release of D-serine from astrocytes," Nature, vol.