loss of heterozygosity


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loss of heterozygosity

[¦lȯs əv ‚hed·e·rō·zī′gäs·əd·ē]
(genetics)
In a heterozygote, the loss of one of the two alleles at one or more loci in a cell lineage or cancer cell population due to chromosome loss, deletion, or mitotic crossing-over. Abbreviated LOH.
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Loss of heterozygosity on chromosome 22 in sporadic schwannoma and its relation to the proliferation of tumor cells.
Furthermore, it has been shown that functional inactivation of KLF6 in various types of cancers such as prostate, ovary and colon, is caused by somatic mutations, loss of heterozygosity (LOH) and silencing by hypermethylation of its promoter (DiFeo et al., 2009; Cho et al., 2006; Sangodkar et al., 2009).
In normal cells carrying mutations in malignant genes, loss of heterozygosity by mitotic recombination may unchain a neoplastic mechanism.
[3] Nonstandard abbreviations: miRNA, microRNA; CLL, chronic lymphocytic leukemia; LOH, loss of heterozygosity.
Borsatti noted that researchers can easily combine OneSeq with Agilent's free-of-charge SureCall software to integrate data analysis of copy number variations, single nucleotide polymorphisms, indels, and loss of heterozygosity.
For instance, in the female sample there was loss of heterozygosity at the ABO and Rh loci which resulted in very high gene differentiation and
Given that the gradual accumulation of these new mutations--Mullets ratchet--is less of a contributor for asexual decline than the Lynch team's findings on simple loss of heterozygosity and exposure of preexisting, deleterious alleles, evolutionary biologists now will need to look at the persistence of other asexual genomes in a new way, Lynch believes.
The acquired loss of heterozygosity (LOH), resulting in duplication of oncogenes or loss of tumor suppressor genes, is a well-established mechanism in tumor evolution [3, 4].
Recent molecular studies showing loss of heterozygosity of certain tumor suppressor genes in many odontogenic keratocysts have supported this opinion.
Loss of heterozygosity in the VNTR region of intron 1 of P53 in two retinoblastoma cases.
Interestingly, the cancer specimen showed no loss of heterozygosity (LOH), in which one side of the DNA's chromosome becomes inactive because of a mutation.