loss of heterozygosity


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loss of heterozygosity

[¦lȯs əv ‚hed·e·rō·zī′gäs·əd·ē]
(genetics)
In a heterozygote, the loss of one of the two alleles at one or more loci in a cell lineage or cancer cell population due to chromosome loss, deletion, or mitotic crossing-over. Abbreviated LOH.
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Methylation of O6-Methylguanine DNA Methyltransferase and Loss of Heterozygosity on 19q and/or 17p are Overlapping Features of Secondary Glioblastomas with Prolonged Survival.
Major role for a 3p21 region and lack of involvement of the t(3;8) breakpoint region in the development of renal cell carcinoma suggested by loss of heterozygosity analysis.
Loss of heterozygosity in the VNTR region of intron 1 of P53 in two retinoblastoma cases.
In fact, it is suggested that loss of heterozygosity (LOH) at the NF1 locus in conjunction with the inherited mutation of the NF1 gene, indicative of Knudson's two-hit model of tumorgenesis via the tumor suppressor pathway, in GISTs of patients with NF1 may be the underlying pathogenesis for these tumors.
The study was carried out to understand the prognostic relevance of loss of heterozygosity (LOH) for chromosome 11 p13, 11p15 and 16q in 135 cases of Wilm's tumour.
Microsatellite instability and loss of heterozygosity in human pterygia.
Karyotypes and analysis of Loss of Heterozygosity (LOH) are routine procedures to detect DNA deletion and serve as TSG location indicators.
Loss of heterozygosity in malignant gliomas involves at least three distint regions on chromosome 10.
This work details DNA microarray applications for the detection and characterization of genomic DNA-associated copy number alteration, loss of heterozygosity, cytosine methylation, protein binding sites, regulatory elements, and replication timing, with emphasis on higher eukaryote (animal) and cancer genomics.
No loss of heterozygosity was observed between wild and broodstock samples or between broodstock and F1 samples.
The task is daunting and progress has been slow, but two search methods--chromosome copy number analysis and loss of heterozygosity analysis--are generating promising new results.