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(MIT) 1. To fail. A program loses when it encounters an exceptional condition or fails to work in the expected manner.

2. To be exceptionally unesthetic or crocky.

3. Of people, to be obnoxious or unusually stupid (as opposed to ignorant).

4. Refers to something that is losing, especially in the phrases "That's a lose!" and "What a lose!"
This article is provided by FOLDOC - Free Online Dictionary of Computing (foldoc.org)
References in periodicals archive ?
"I don't know if it got lost in the mail or if she misplaced it or just didn't understand it, or if she just forgot' about your letter because this whole thing scares her so much.