However, nuclear [beta]-catenin was not detected in LH-stimulated cells, which is consistent with a recent study that showed, during terminal differentiation of GCs, the WNT/[beta]-catenin pathway is inactive and over-activation of CTNNB1 negatively affects LH-induced ovulation and luteinization
Besides the folliculogenesis, oocyte capacitation and ovulation, GDF9 and BMP15 are still involved in the steroidogenesis, inhibition of luteinization
and differentiation of cumulus and granulosa cells (Gilchrist et al.
Specifically, FSH and LH interact to govern follicle growth, whereas LH induces ovulation and luteinization
of follicles and sustains luteal activity.
Novel signaling pattways that control ovarian follicular development, ovulation, and luteinization
This could impact steroidogenesis, luteinization
, and ovulation by reducing granulosa cell sensitivity to circulating LH.
Where  suggest that one day after luteinization
in vivo, full-length FSH-receptor mRNA was detectable at low levels in the newly-formed corpus luteum, their results showed that granulosa cell luteinization
in cattle is associated with a change in splicing of the FSH-receptor primary transcript.
The most common causes are gestational trophoblastic disease (hydatidiform mole or choriocarcinoma), hyperstimulation secondary to infertility treatments, and extensive luteinization
of theca cells, usually in a multiple gestation.
However, this complex process initiated by ovulation and followed by luteinization
, similar to wound healing or tumor formation, needs to be highly regulated and coordinated.
Due to its similarity to LH, urine-derived hCG has been used to trigger ovulation and luteinization
and to support the corpus luteum.
Low energy consumption inhibits the function of the ovaries by reducing the hyphotalamic release of the luteinization
5 shows the EG/PG ratio together with the concentration of LH (actually hCG used to initiate luteinization
before egg collection) determined by a time-resolved fluorescence immunoassay (Wallac 1244-006).