Inhibition of ATP Citrate Lyase
(ACL) by bempedoic acid reduces cholesterol biosynthesis and lowers LDL-C by up-regulating the LDL receptor.
In partial forms patients have normal 17[alpha]-hydroxylase activity, while 17,20 lyase
activity is absent.
3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) lyase
deficiency leads to a reduced ability to synthesize ketones, which are the primary energy source of the brain when glucose is unavailable.
Liver-specific ATP-citrate lyase
inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.
The main enzyme activities in a commercial pectinase are pectin lyase
, pectin methyl-esterase and polygalacturonase.
 This drug inhibits the enzyme adenosine triphosphate citrate lyase
, which results in a decreased production of both cholesterol and TGs.
Calcium increases the resistance of potato stems and tubers to maceration by pectolytic enzymes such as pectate lyase
and polygalacturonase .
Due to the capacity to synthesize and secrete several extracellular enzymes including pectate lyase
, pectin lyase
, polygalacturonase, cellulase, protease, and elicitor protein harpin, the soft rot bacteria Pectobacterium is responsible for significant, global economic losses of crops and ornamental plants, both in the field and in storage.
HCA has also been shown in tests to combat fat loss by inhibiting a key fat-producing enzyme (Citrate Lyase
The enzymes hydroxymethylglutaryl-CoA reductase, type III geranylgeranyl diphosphate synthase, phosphomevalonate kinase, hydroxymethylglutaryl-CoA synthase, prenylcysteine oxidase/farnesylcysteine lyase
, and protein farnesyltransferase subunit beta are each coded by two copies of the genes.
The papers highlight the following aspects: the action of Sph in various phases of acute inflammatory response, the behavior of enzymes that produces ceramides (Cer), those that utilize Cer to produce other bioactive molecules such as Cer-1-phosphate (Cer1P) and sphingosine-1-phosphate (S1P), and those that transform S1P such as S1P phosphatase and S1P lyase
in inflammation and cancer.
By breaking this bond using carbon-phosphorus lyase
(CP-lyase), they release the inorganic phosphate that is critical to life.