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Out of the 52 cases diagnosed as NPC, 37 were squamous cell carcinomas (WHO Grade I), nine were non-keratinizing squamous carcinomas (WHO grade II), and six were lymphoepithelioma type carcinomas (WHO grade III).
Adsay et al (46) have described a subtype of ductal carcinoma with a foamy gland pattern having a deceptively benign appearance and Wilenz et al (47) have identified a medullary carcinoma characterized by a solid, sometimes lymphoepithelioma like pattern of growth, usually wild type (non-mutated) KRAS, and occasional multicentricity.
nonkeratinizing undifferentiated form also known as lymphoepithelioma is most common.
Prostatic adenocarcinoma has many histological variants including atrophic, pseudohyperplastic, foamy gland, colloid, signet ring, lymphoepithelioma like and sarcomatoid variant.
There was only one case of nasopharyngeal lymphoma and one case of lymphoepithelioma found, representing 3.
Tumors with similar morphology occur at salivary gland, stomach, thymus, urogenital system and lung which are known as Lymphoepithelioma like carcinoma (LELC) Its incidence in kidney is extremely rare.
Unlike nasopharyngeal lymphoepithelioma, LELC of the urinary tract is not associated with the Epstein-Barr virus (EBV) on immunohistochemical analysis.
We report a case of unilateral tonsillar lymphoepithelioma with extension into the ipsilateral parapharyngeal space, and we review the clinical, histologic, and radiographic findings of the case.
This undifferentiated carcinoma is made up of cells of varying morphology, and it frequently contains clumps of benign T cells intermixed within the tumor mass; as a result, it is also called a lymphoepithelioma.
The histologic features of the right nasopharyngeal specimen were consistent with a typical nasopharyngeal carcinoma of the lymphoepithelioma subtype.
3) Morphologically, MLEL resembles lymphoepithelioma (undifferentiated nasopharyngeal carcinoma with lymphoid stroma), and it is often difficult to distinguish MLEL from metastatic nasopharyngeal carcinoma of the salivary gland.