lymphokine-activated killer cell


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lymphokine-activated killer cell

[¦lim·fə‚kīn ¦ak·tə‚vād·əd ′kil·ər ‚sel]
(immunology)
A cytotoxic cell that is able to lyse certain cell lines resistant to natural killer cells.
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Interleukin-12 (IL-12) is an immuno-regulatory cytokine [1] that can activate NK cells, generate lymphokine-activated killer cells (LAKs), and induce interferon-[gamma] (IFN-[gamma]) production and T-cell proliferation [2].
Nevertheless, it has been shown that CB-derived NK and lymphokine-activated killer cells are able to lyse non-cultured fresh leukemia blasts, readily respond to IL-2 and IL-12, and mediate relatively high levels of apoptosis-mediated cytotoxicity against target cell lines (18), (19).
A lymphokine, previously designed interleukin T and produced by a human adult T cell leukemia line, stimulates T cell proliferation and the induction of lymphokine-activated killer cells. Proc.