lysin


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Lysin

A term used to describe substances that will disrupt a cell, with the release of some of its constituents. Unless the damage is minor, this action leads to the death of the cell. Lysins vary in the range of host species whose cells they will attack and in their requirements for accessory factors for lysis; the immune lysins are strictest in their requirements. Erythrocytes are lysed by a wide variety of chemicals, including water and hypertonic salt solutions, which displace the osmotic pressure from that of isotonicity. They are also susceptible to surface-active substances, such as saponin. Many bacteria, such as the staphylococcus and the streptococcus, elaborate one or more hemolysins that will lyse erythrocytes from certain, although not all, species of animals. See Lytic reaction

lysin

[′līs·ən]
(immunology)
A substance, particularly antibodies, capable of lysing a cell.
References in periodicals archive ?
In June 2019, the Congressionally Directed Medical Research Programs awarded the Company $7.2 million in funding over the course of three years from the Military Infectious Diseases Research Program, United States Army Medical Research and Development Command, to advance its lysin candidate, CF-296, through IND-enabling studies.
Another phage-derived protein is represented by the virion-associated peptidoglycan hydrolase (VAPGH, or tail-associated lysin).
The assets purchased include intellectual property for multiple lysins and for the rapid development of lysin solutions.
Expression of M6 and M7 lysin in Mytilus edulis is not restricted to sperm, but occurs also in oocytes and somatic tissue of males and females.
X-ray crystal structure of the streptococcal specific phage lysin PlyC.
Lillehoj and her colleagues have identified and applied for a patent for one of the immune molecules, called "NK lysin."
have signed a contract to support the process development and cGMP manufacture of CF-301, ContraFect's Staphylococcal-specific bacteriophage lysin. CF-301 is ContraFect's lead compound with potent activity against all forms of Staph infections, including methicillin-resistant (MRSA) and vancomycin-resistant strains (VISA/VRSA).
Among the components found in the plasma of planorbids are lectin, lysin, agglutinin and substances similar to lymphocin, hydrogen peroxide, as well as other microbian factors (Lie et al., 1980; Boswell and Bayne, 1986; Connors and Yoshino, 1990; Castillo and Yoshino, 2002).
I separated the water, the fats, the oils, the gums, the resins, sugars, starches, pectoses, pentoses, pentosans, legumen, lysin, the amino and amido acids.
More recent research indicates that a phage bacterial lysin (PlyG, from phage-[gamma]) can lyse vegetative B.