Initial subclinical infection probably occurs in childhood; however, in severe immunosuppression, reactivation of the virus leads to a lytic infection
of oligodendrocytes in the brain.
This lytic infection
leads to cognitive and motor dysfunction (the syndrome PML) and is fatal in 50 percent or more of patients.
Of the genes tested, IFN-[beta] and IFN-[gamma] were upregulated in the CT of both infected lines during lytic infection
demonstrated the possibility of a temperature-dependent reactivation of CyHV-3 lytic infection
several months after initial exposure to the virus (32) .
Probably such effects will be of limited significance within the context of an active, productive and lytic infection
, where the host cell has no long-term future.
Nevertheless, it gives no information on the various patterns of expression of the latent genes or on the presence of a lytic infection
Mouse cytomegalovirus microRNAs dominate the cellular small RNAs profile during lytic infection
and show features of post-transcriptional regulation" Doelken et al.
PML, caused by the John Cunningham (JC) virus, results from lytic infection
of predominantly astroglial cells.
Acute disease manifests itself as a lytic infection
of rapidly dividing cells; chronic disease reflects a restricted or abortive infection of specific cell types (1).