isolation and partial cherecterization of lytic phage against Salmonalla Abortusequi.
The use of lytic phages to inactivate bacteria and the application of the phage lysate as a vaccine antigen is an alternate approach to develop candidate vaccine against bacterial disease but it has been poorly explored.
Screening of different sewage samples of GADVASU, Ludhiana, by soft agar overlay method yielded a lytic phage against S.
In our effort to isolate novel staphylococcal phages, 30 sewage samples were screened and finally a lytic phage against S.
Phage PSAE-1 was reoprted to be first lytic phage
against Salmonella Abortusequi in India (3) was revived, purified and produced in bulk.
Therefore, in this study the infection ability of three lytic phages
SA, SANF and SA2 was determined against ten isolates of Staphylococci and one Micrococcus, isolated from five raw milk samples.
The literature recognizes as evidence of the lytic activity of bacteriophages, reduction in the optical density of host bacteria co-cultivated with lytic phages
in relation to bacterial cultures without the phage .
2003) and more recently also lytic phages
(Shivu et al.
multiply until the bacterial membrane bursts apart, releasing endotoxins (produced by the bacterium in self-defense) and a new population of bacteriophages.
A further potential undesirable side effect, particularly when natural lytic phages
are injected to combat infection, is the creation of immunogenic reactions in the patient by having large uncontrolled amounts of phages in circulation.
Because of the natural capacity of many lytic phages
, phages of B.
disrupt bacterial metabolism and cause the bacterium to lyse.