Perfusion

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perfusion

[pər′fyü·zhən]
(physiology)
The pumping of a fluid through a tissue or organ by way of an artery.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Perfusion

 

a method of passing physiological solutions, blood, blood substitutes, or other fluids through the blood vessels of an organ, a part of the body, or the entire body. Perfusion may be performed on organs completely removed from the body or on organs within the body but isolated from the general vascular system. Widely used in experimental physiology, it permits preservation of the vital activities of organs for a certain period, enabling the study of organ functions and of the effect of hormones, mediators, enzymes, and medicinal substances on physiological systems and the entire body. The method is used in various branches of surgery, including transplantation of organs and tissues. Perfusion of the entire body is used, for example, during heart surgery.

The term “perfusion” also designates the supplying of blood to organs of the body under natural conditions (for example, perfusion of the kidneys, brain, or other organs), which is determined by the state of cardiac activity and local vascular tonus.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The prognostic value of renal resistance during hypothermic machine perfusion of deceased donor kidneys.
Westerkamp et al., "Normothermic machine perfusion reduces bile duct injury and improves biliary epithelial function in rat donor livers," Liver Transplantation, vol.
Carlucci et al., "Subnormothermic machine perfusion protects steatotic livers against preservation injury: a potential for donor pool increase?" Liver Transplantation, vol.
Leuvenink et al., "Determination of an adequate perfusion pressure for continuous dual vessel hypothermic machine perfusion of the rat liver, " Transplant International, vol.
The mean tGST activity and HFABP concentration (per 100 g of kidney tissue) at [t.sub.4] (4th hour of machine perfusion) for uncontrolled donors were 143 [+ or -] 18 U/L and 184 [+ or -] 13 [micro]gL, respectively.
Systematic review and meta-analysis of hypothermic machine perfusion versus static cold storage of kidney allografts on transplant outcomes.
The use of gradual rewarming has shown promise for this population of liver grafts [28-31] and may play an important role moving forward in utilizing machine perfusion after periods of SCS.
Weeder et al., "Functional human liver preservation and recovery by means of subnormothermic machine perfusion," Journal of Visualized Experiments, no.
Today, hypothermic machine perfusion of kidneys in the transplant clinic typically utilizes one of two types of perfusion machines: the Waters (Waters Medical Systems) RM3 or the ORS (Organ Recovery Systems) LifePort.
*In case delayed graft function occurred, its duration was shorter after machine perfusion compared with cold storage (10 days vs.
Research has shown that machine perfusion can safely prolong the average cold storage time for kidneys from the current 18 hours to 35 hours or more.
ORS says the study will employ the company's machine perfusion protocols, which involve passing chemical solutions through organs to minimize tissue damage, as one of its main criteria for predicting the eventual success or failure of extended criteria kidneys.

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