Initiated in 2013, the Merck collaboration leverages Ra Pharma's Extreme Diversity platform aimed at producing
macrocyclic peptides that are designed to have the diversity and specificity of antibodies, while retaining the pharmacologic attributes of small molecules, with the potential to allow for the rapid identification, design, and development of drug-like peptides with high stability, bioavailability, cell permeability, and potency.
It would be of interest to find out if linear and
macrocyclic GBCAs are retained, and if chelation treatment is an option for linear and
macrocyclic GBCAs.
Dung beetle (Coleoptera: Scarabaeinae) diversity and seasonality in response to
macrocyclic lactones use at cattle ranches in the Mexican Neotropics.
Cyclenium Pharma is an emerging, privately-held pharmaceutical research and development company exploiting its proprietary next generation CMRT
macrocyclic drug discovery technology and QUEST screening library for the discovery and development of novel small molecule therapeutic agents to address areas of unsatisfied medical need.
Vicens, "Special Calixarenes, Synthesis and Properties," in Calixarenes: A Versatile Class of
Macrocyclic Compounds, vol.
Transition Metal Complexes Bearing
Macrocyclic Ligands
Macrocyclic Gadovist[R] elicited lower immune responses from macrophages with marginal ROS elevation and potential mitochondrial membrane suppression.
The concept of indicator-displacement assay (IDA) has attracted considerable attention with the development of host-guest chemistry, which exploits the potential of artificial receptors, particularly
macrocyclic hosts, because of its promising applications in molecular recognition and sensing [7].
Macrocyclic PBT, also known as c-PBT, is produced from the ring expansion polymerization of CBT oligomers [25] as given in Figure 1.
For now, fidaxomicin, a narrow spectrum
macrocyclic antibiotic, may be appropriate for those at high risk for relapse and/or those requiring concomitant antibiotics--but its high price tag may be prohibitive.
Of the two types of gadolinium, linear and
macrocyclic, the PRAC-EMA recommended the former type no longer be marketed as it was associated with greater retention of the GBCA (FDA, 2017).
Macrocyclic lactone is a strong pesticide for cow, pig and horse.
