Initiated in 2013, the Merck collaboration leverages Ra Pharma's Extreme Diversity platform aimed at producing macrocyclic
peptides that are designed to have the diversity and specificity of antibodies, while retaining the pharmacologic attributes of small molecules, with the potential to allow for the rapid identification, design, and development of drug-like peptides with high stability, bioavailability, cell permeability, and potency.
It would be of interest to find out if linear and macrocyclic
GBCAs are retained, and if chelation treatment is an option for linear and macrocyclic
Dung beetle (Coleoptera: Scarabaeinae) diversity and seasonality in response to macrocyclic
lactones use at cattle ranches in the Mexican Neotropics.
Cyclenium Pharma is an emerging, privately-held pharmaceutical research and development company exploiting its proprietary next generation CMRT macrocyclic
drug discovery technology and QUEST screening library for the discovery and development of novel small molecule therapeutic agents to address areas of unsatisfied medical need.
Vicens, "Special Calixarenes, Synthesis and Properties," in Calixarenes: A Versatile Class of Macrocyclic
Transition Metal Complexes Bearing Macrocyclic
Gadovist[R] elicited lower immune responses from macrophages with marginal ROS elevation and potential mitochondrial membrane suppression.
The concept of indicator-displacement assay (IDA) has attracted considerable attention with the development of host-guest chemistry, which exploits the potential of artificial receptors, particularly macrocyclic
hosts, because of its promising applications in molecular recognition and sensing .
PBT, also known as c-PBT, is produced from the ring expansion polymerization of CBT oligomers  as given in Figure 1.
For now, fidaxomicin, a narrow spectrum macrocyclic
antibiotic, may be appropriate for those at high risk for relapse and/or those requiring concomitant antibiotics--but its high price tag may be prohibitive.
Of the two types of gadolinium, linear and macrocyclic
, the PRAC-EMA recommended the former type no longer be marketed as it was associated with greater retention of the GBCA (FDA, 2017).
lactone is a strong pesticide for cow, pig and horse.