Morphological Patterns of Anaemia Patterns of Blood Picture Number of Patients (%) Baseline (n = 100) Macrocytic
10 (10.0) Microcytic hypochromic 23 (23.0) Normocytic hypochromic 25 (25.0) Normocytic normochromic 42 (42.0) Table 5.
Considering the association between decreased B12 absorption and PPI use, together with macrocytic
anemia findings on his CBC and the physical exam findings of enlarged tongue and lip tingling, it is likely this patient also has a B12 deficiency.
On the basis of red cell indices (mean corpuscular volume [MCV]), patients having anemia were further classified as normocytic normochromic (MCV 80-96 fl), microcytic hypochromic (MCV <80 fl), and macrocytic
(MCV >96 fl) and were investigated to find the etiology as well as to rule out any secondary causes of anemia, if found such patients were excluded from the study.
anaemia was, however, more common among HIV-infected patients, most likely due to the use of azidothymidine.
The mean red blood cell corpuscular volume (MCV) was classified as microcytic, normocytic, and macrocytic
according to MCV levels < 80 fl, 80-100 fl, and >100 fl, respectively .
In addition, the infant developed macrocytic
, hyperchromic anemia.
In addition to the very high TSH and low fT4 levels, patient had macrocytic
anaemia, mild pericardial effusion on echocardiography, hyponatraemia in the background of normal hydration status, elevated liver enzymes, and high CK value in support of the above diagnosis.
Pernicious anemia is an autoimmune disorder and classically manifests as macrocytic
anemia with hypersegmented neutrophils on peripheral smear.
Additionally, he did not present any vitamin deficiencies or any blood count disturbances, particularly iron deficiency or macrocytic
anemia, which could be an etiologic factor as pointed out by Sharma et al.
Anaemia could be associated with a microcytic, normocytic or macrocytic
picture (Figure 1).
The spectrum of etiologies associated with macrocytic
anemia includes nutritional deficiencies (e.g.
Interestingly the patient presented had mild macrocytic
anemia (hemoglobin 10.7 g/dL and mean corpuscular volume 103 [my][m.sup.3]).