macroencapsulation

macroencapsulation

[‚mak·rō·in‚kap·sə′lā·shən]
(cell and molecular biology)
The envelopment of a large mass of xenotransplanted cells or tissue in planar membranes, hollow fibers, or diffusion chambers to isolate the cells from the body, thereby avoiding the immune responses that the foreign cells could initiate, and also to allow the desired metabolites (such as insulin and glucose for pancreatic islet cells) to diffuse in and out of the membrane.
References in periodicals archive ?
The Cell Pouch is a novel, proprietary, scalable, implantable prevascularized macroencapsulation device for the long term survival and function of therapeutic cells (donor, stem cell derived cells and xenogeneic cells) which then release proteins and/or hormones as required to treat disease.
The Cell Pouch is a novel, proprietary, scalable, implantable prevascularized macroencapsulation device for the long-term survival and function of therapeutic cells (donor, stem cell derived cells and xenogeneic cells) which then release proteins and/or hormones as required to treat disease.
Radke et al., "Macroencapsulation of human cartilage implants: pilot study with polyelectrolyte complex membrane encapsulation," Biomaterials, vol.
Lim, Macroencapsulation of Quorum Quenching Bacteria by Polymeric Membrane Layer and its Application to MBR for Biofouling Control, J.
The VC-01 combination product employs a macroencapsulation device that is designed to protect the implanted cells from the patient's immune system.
To immune-isolate the islet cells in this manner, one of two strategies is typically utilized, microencapsulation or macroencapsulation. For the first, one islet to four islets are encapsulated in a microsphere of polymer [2].
MAILPAN (MAcroencapsulation of PANcreatic Islets) is a prototype of bioartificial pancreas usable in the human designed to treat type 1 diabetic patients.
Gong et al., "Nanoporous alumina capsules for cellular macroencapsulation: transport and biocompatibility," Diabetes Technology and Therapeutics, vol.
Although hollow-fibre membranes also have their size limits (11), the impetus for larger devices has nonetheless driven the development of polymers especially suitable for macroencapsulation. Recent developments with AN-69 copolymers have attempted to increase existing encapsulation size limits.
The bill defines engineered seed as seed produced by methods "used to modify genetically organisms to influence their growth and development by means that are not possible under natural conditions or processes." According to the bill, those methods include cell fusion, microencapsulation and macroencapsulation, and recombinant DNA technology.
WCS plans to promptly begin tests using EKOR on certain wastes that can use macroencapsulation technology to comply with RCRA, TSCA, and/or radiological criteria.
Previously, Envirocare commercialized another BNL-developed mixed-waste process called macroencapsulation. The technique, which also uses an extruder, embeds large pieces of hazardous waste in polyethylene inside large containers.