macroglobulin


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macroglobulin

[¦mak·rə′gläb·yə·lən]
(biochemistry)
Any gamma globulin with a sedimentation constant of 195.
References in periodicals archive ?
An elevation of 39 % was exhibited by alpha-2- macroglobulin (190 kDa) in patients of rheumatic heart disease.
This phenomenon has also been suggested for increased [alpha]-2 macroglobulin concentrations in cervical carcinoma (59).
Some widely used algorithms include the APRI (AST-to-platelets ratio index), the Fibrotest (aptoglobin, alpha-2 macroglobulin, apolipoprotein A1, gamma-glutamyl transpeptidase, and bilirubin), the Hepascore (bilirubin, gamma-glutamyl transpeptidase, haluronic acid, alpha-2 macroglobulin, age, sex), and the BARD (BMI, AST/ALT ratio, diabetes).
Not much is known about this macroglobulin in terms of disease except in the case of renal disease.
Serum was collected for analyses of the following parameters: a-fetoprotein (AFP), [alpha]-2 macroglobulin ([alpha]-2M) and tumor necrosis factor (TNF-[alpha]) for rats were done by ELISA according to the techniques of Watanabe et al (21),Hoyer et al (22) and Whittle et al (23), respectively.
However, this fraction was still contaminated with an additional protein, probably alpha 1 macroglobulin (a1M), which has similar physicochemical properties to [alpha]2M (8,9).
In addition, preliminary testing suggests that its lytic activity is localized to the site of delivery because within seconds of moving away from the clot and into the general circulation it is inhibited by alpha-2 macroglobulin, a naturally occurring protein in our blood.
Alfimeprase is inhibited within seconds of moving away from the clot and into the general circulation by alpha-2 macroglobulin, a naturally occurring protein in our blood.
It encodes alpha-2 macroglobulin, a protein that deactivates proteases, enzymes that carve up other proteins.