Major Finding: The risk for a major depressive episode
among current heavy smokers was 26.
The efficacy of Wellbutrin[R] XL for the prevention of seasonal major depressive episodes
was established in three, double-blind, placebo-controlled trials in adult outpatients with a history of major depressive disorder with an autumn-winter seasonal pattern, as defined by Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria.
Major Finding: The 139 patients with high medical comorbidity were significantly more likely than were those with low medical comorbidity to present in a current major depressive episode
Women with a current major depressive episode
had an almost 11-fold increased risk of suicidal ideation in the postpartum period, based on multivariate analysis (odds ratio 10.
Those adolescents who reported a major depressive episode
in the past year also were more likely to report illicit drug use in the past year, as well as daily cigarette use and heavy alcohol use in the past month.
Comment: In studies of 1,042 adults with a history of a major depressive episode
with an autumn-winter seasonal pattern, participants started treatment or placebo in the fall, before the onset of symptoms, and stopped in the early spring.
The approvable letter covers use of the system on patients with chronic or recurring depression in a major depressive episode
that has not responded to at least four adequate antidepressant treatments.
The current study, conducted by Minoru Takeshima and colleagues from the Ishikawa Prefectural Takamatsu Hospital, Kahoku City, Japan, comprised 87 patients hospitalized on the psychiatric ward with 105 major depressive episode
The efficacy of bupropion in the treatment of a major depressive episode
was established using the immediate-release formulation in two four-week controlled trials of inpatients and one six-week controlled trial of outpatients who met criteria for major depression.
Patients met DSM-IV-TR criteria for a major depressive episode
in the context of major depressive disorder.
Persistent alcohol use during the 3-year follow-up was predicted by major depressive episode
(odds ratio 1.
In an elderly patient, it's often difficult or impossible to differentiate the reversible cognitive changes that may occur with a major depressive episode
, known as pseudodementia, from those of true early dementia.