For severe depression, the guidelines concur that the following firstline treatment options apply: (i) a combination of an antidepressant and psychotherapy (either CBT or IPT); (ii) electroconvulsive therapy (ECT) (6 to 10 treatments, maximum of 20, WFSBP guidelines recommend bilateral rather than unilateral ECT); or (iii) a combination of an antidepressant with an antipsychotic agent for a major depressive episode
with psychotic features.
A local study by Wong (27) on psychiatric morbidity of patients with remitted GD showed a prevalence of 17.3% for current depressive disorders, and 6.4% for major depressive episodes
. This was comparable to the figures from this study.
This is the first study showing the reliability of the SCID for major depressive episode
in adolescents and paves the way for the testing of other modules of the SCID in adolescents or other specific populations.
The report defines a major depressive episode
as a period of two weeks or longer during which there is depressed mood or loss of interest or pleasure and at least four other symptoms that reflect a change in functioning, such as problems with sleep, eating, and self-image.
(13) If a patient has had 1 or more major depressive episodes
and l or more hypomanic episodes but no mixed or manic episodes, the diagnosis is bipolar II disorder.
The mood in a major depressive episode
often is described by the person as depressed, sad, hopeless, discouraged, or "down in the dumps" (APA, 2000a).
Almost six per cent of girls aged 12 to 14 years old said they had a high risk of having a major depressive episode
in the year before the survey as opposed to two per cent of boys the same age.
When officers fail to perform at the optimal level for an extended period of time, the problem could be related to a major depressive episode
. Clinicians agree that depression often plays a major role in suicide.(6) While anyone can have an occasional gloomy day, people dealing with depression suffer from a deeper, long-term malaise.
Conditions included in the new order are catatonia or a severe major depressive episode
associated with major depressive disorder or bipolar disorder in patients over the age of 13 years who are resistant to treatment or who require a rapid response because of the severity of their psychiatric or medical condition, according to an FDA press release.
LATUDA is indicated for monotherapy treatment of adult and pediatric patients (10 to 17 years) with major depressive episode
associated with bipolar I disorder (bipolar depression) and adjunctive treatment with lithium or valproate In adult patients with bipolar depression.
Each year approximately 21 million Americans, or about 16% of the population, suffer a major depressive episode
. The lifetime prevalence of depression in women is 10% to 25%, and it is 5% to 12% for men.