major histocompatibility complex


Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.
Related to major histocompatibility complex: human leukocyte antigen

major histocompatibility complex

[′mā·jər ¦hi·stō·kəm′pad·ə′bil·əd·ē ′käm‚pleks]
(immunology)
In vertebrates, a family of genes that encode cell surface glycoproteins that regulate interactions among cells of the immune system, some components of the complement system, and perhaps other related functions connected with intercell recognition. Abbreviated MHC.
References in periodicals archive ?
Peterlin, "Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages," Journal of Biological Chemistry, vol.
Spies, "A second lineage of mammalian major histocompatibility complex class I genes," Proceedings of the National Academy of Sciences of the United States of America, vol.
Stear et al., "An ovine major histocompatibility complex DRB1 allele is associated with low faecal egg counts following natural, predominantly Ostertagia circumcincta infection," International Journal for Parasitology, vol.
Milinski, and T Boehm, "Does intra-individual major histocompatibility complex diversity keep a golden mean?" Philosophical Transactions of the Royal SocietyB: Biological Sciences, vol.
Major histocompatibility complex class II alleles and haplotypes and blood groups of four Amerindias tribes on northern Colombia.
class II alleles and the FVIII inhibitors in Thai hemophilia patients was further investigated in this study, as recent studies have indicated that inhibitor formation depends upon an adequate T-cell response by major histocompatibility complex class II molecules to FVIII resulting from the presentation of FVIII protein antigen to T-cell receptors (18-21).
Khaitov, M., Alekseev, P., 2001., "The physiological role of major histocompatibility complex of man", Zh.
The correlation between increased tumourigenicity and a decrease in major histocompatibility complex (MHC) Class I expression has been well established.
The research used a technique known as micropipette adhesion frequency assay to study the mechanical interactions between T cells and the antigen, known as a peptide major histocompatibility complex (pMHC)--a glycoprotein.
(3,4) It required another 20 years before evidence of genetic associations outside of the major histocompatibility complex (MHC) were convincingly demonstrated, with the discovery of associations with PTPN22 in Caucasian populations (5) and PADI4 in Asian RA populations.
Besides lung rejection, there are risk factors, which include mismatching of HLA (the major histocompatibility complex in humans), and pneumonias caused by cytomegalovirus.

Full browser ?