malaria pigment

malaria pigment

[mə′ler·ē·ə ‚pig·mənt]
(pathology)
Dark-brown, amorphous, microcrystalline and birefringent pigment found in parasitized erythrocytes, especially with malarial parasites, and in littoral phagocytes of spleen, liver, and bone marrow.
References in periodicals archive ?
Though the exact mechanism of cardiac complications associated with malaria is not known, various proposed pathogeneses include (1) mechanical blockage of capillaries by malaria parasite and parasitized red blood cells, (2) myocardial damage by macrophages containing malaria pigment, (3) myocardium damage by tumor necrosis factor, and (4) hypoglycemia and acidosis caused by severe malaria may affect myocardial function.
While the other studies used only the presence of the malaria parasite as the diagnostic criterion, this study used the malaria parasite and/or malaria pigment, so that past or chronic malaria, which are more likely to be associated with structural and functional changes in placenta than acute malaria, could also be diagnosed.
For each histological section per animal not <ten microscopic fields were randomly selected and examined for any histopathological changes, such as malaria pigment deposition and sequestered RBCs.
Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis.
Clinical and laboratory criteria for severe malaria (any one or combination of these criteria applies) Clinical Impaired consciousness, multiple convulsions Respiratory distress, acidotic breathing, pulmonary oedema Circulatory collapse Jaundice Bleeding Prostration Laboratory Hypoglycaemia (blood glucose <2.2 mmol/L) Acidosis (plasma bicarbonate <15 mmol/L or serum lactate >5 mmol/L) Hepatic transaminases >3 times normal Renal impairment (serum creatinine >265 [micro]mol/L or rapidly rising creatinine or urine output <400 mL/day in an adult) Haemoglobin <5 g/L Parasitaemia [greater than or equal to] 5% [greater than or equal to] 5% neutrophils contain malaria pigment Presence of schizonts of P.
Also phagocytosis of Malaria pigment in acute Malaria by monocytes is seen.
Hemozoin or malaria pigment is a crystalline form of free heme.
Phagocytosis of malaria pigment is by monocyte/macrophages and less frequently by neutrophils [15, 20, 21].
Association of intraleukocytic Plasmodium falciparum malaria pigment with disease severity, clinical manifestations, and prognosis in severe malaria.
Presence of falciparum schizonts and/or malaria pigment in 5% or more of neutrophils on a blood film are considered to be poor prognostic signs (12,77,78).
Clinical and laboratory criteria for severe malaria Clinical Impaired consciousness, multiple convulsions Respiratory distress, acidotic breathing, pulmonary oedema Circulatory collapse Jaundice Bleeding Prostration Laboratory Hypoglycaemia (blood glucose <2.2 mmol/l) Acidosis (plasma bicarbonate <15 mmol/l or serum lactate >5 mmol/l) Hepatic transaminases >3 times normal Renal impairment (serum creatinine >265 [micro]mol/l or rapidly rising creatinine or urine output <400 ml/day in an adult) Haemoglobin <5 g/l Parasitaemia [greater than or equal to] 5% [greater than or equal to] 5% neutrophils contain malaria pigment Presence of schizonts of P.
Sometimes parasites cannot be found in peripheral blood smear from patients with malaria, but malaria pigment may be seen in circulating phagocytic leucocytes.