Malate Dehydrogenase

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malate dehydrogenase

[′ma‚lāt dē′hī·drə·jə‚nās]

Malate Dehydrogenase


an enzyme of the oxidoreductase class widely distributed in animal and plant cells, where it catalyzes the dehydrogenation of malic acid to oxalacetic acid in the tricarboxylic acid cycle. In higher plants and animals there are two different malate dehydrogenases, one localized in the mitochondria and the other in the soluble fraction of the cell.

Decarboxylating malate dehydrogenase (malic enzyme) catalyzes the readily reversible formation reaction of malic acid from pyruvic acid and CO2, as well as the decarboxylation of oxalacetic acid.

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The interpretation of the malic acid dehydrogenase phylogenies is complicated by potential switches in substrate specificities between lactic and malic acid dehydrogenases.