Malate Dehydrogenase

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malate dehydrogenase

[′ma‚lāt dē′hī·drə·jə‚nās]
(biochemistry)
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Malate Dehydrogenase

 

an enzyme of the oxidoreductase class widely distributed in animal and plant cells, where it catalyzes the dehydrogenation of malic acid to oxalacetic acid in the tricarboxylic acid cycle. In higher plants and animals there are two different malate dehydrogenases, one localized in the mitochondria and the other in the soluble fraction of the cell.

Decarboxylating malate dehydrogenase (malic enzyme) catalyzes the readily reversible formation reaction of malic acid from pyruvic acid and CO2, as well as the decarboxylation of oxalacetic acid.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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However, in addition to the archaeal-type coupling factor ATPase, the malic acid dehydrogenases found in Deinococcaceae do not group with the typical bacterial homologs, but closer to the eukaryotes.