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Failure of a tissue or organ to achieve complete development.



or hypogenesis, underdevelopment of a tissue, organ, part of the body, or entire organism. Just as with aplasia, the basis of hypoplasia is impairment of the interuterine development of the fetus as a result of the effect of radiant energy on the mother’s organism, imbalance in nutrition, and certain infections transmitted from the mother to the fetus, such as German measles, toxoplasmosis, or poliomyelitis.

References in periodicals archive ?
Evaluation of mandibular hypoplasia in patients with hemifacial microsomia: a comparison between panoramic radiography and three-dimensional computed tomography.
Studies in knockout of Nog shows abnormalities in the neural tube and the somites and mandibular defects ranging over a range of phenotypes from the mandibular hypoplasia, passing through an intermediate phenotype micrognathia (poor formation of the jaw) to agnathia (absence of mandibular formation) (88,89).
In utero exposure to isotretinoin (13-cisretinoic acid), an analog of vitamin A used to treat cystic acne, is associated with a characteristic pattern of malformations, including abnormal ear development, a flat nasal bridge, mandibular hypoplasia, cleft palate, hydrocephalus, neural tube defects, and conotruncal heart defects (Lammer et al.
DISCUSSION: Goldenhar described a syndrome with epibulbar dermoids, pre-auricular appendages and mandibular hypoplasia (hemifacial microsomia) which was expanded by Gorlin etal to "occuloauriculovertebral spectrum".
Distraction osteogenesis is an alternative treatment method for the correction of mandibular hypoplasia.