Mast Cell

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mast cell

[′mast ‚sel]
A connective-tissue cell with numerous large, basophilic, metachromatic granules in the cytoplasm.

Mast Cell


(also called mastocyte or labrocyte), a reticular connective tissue cell in animals and man. The number of mast cells depends on the species and on the functional state of the connective tissue. The mast cell contains metachromatic cytoplasmic granules; the size and number of granules depend on the species and on the maturity and functional state of the cell. Mast cells contain a number of physiologically active substances, notably heparin, histamine, and serotonin. Consequently, it is believed that the mast cell plays a role in anaphylaxis, inflammation, and blood clotting. Mast cells rarely divide by mitosis. The principles of their origin and reproduction remain obscure.

References in periodicals archive ?
On histopathological examination of the cutaneous lesions, mast cell accumulation is found and the mast cells are differentiated by metachromatic staining by Giemssa and Toluidine dyes (26).
In addition, cell lysates (1 million cells per 100 [micro]L of lysis buffer) from mast cells were also prepared.
the mast cells were counted, similar to our study, which showed that neuroproliferation in appendix was associated with increased mast cell density.
Type 3 variant includes patients with coronary thrombosis (including stent thrombosis), in whom aspirated thrombus specimens stained with haematoxylin-eosin and Giemsa demonstrate the presence of eosinophils and mast cells, respectively.
Rogue mast cell response and histamine overload has been seen in clinical practice, yet often discounted due to seemingly unrelated symptoms.
This is based on its mode of action because the drug must already be present to prevent mast cell degranulation.
Guideline recommends topical antihistamines or mast cell stabilizers
Mast cell proteases as protective and inflammatory mediators.
Mast cell infiltration and degranulation in colonic mucosa in the irritable bowel syndrome.
In addition to the test for genetic defects within the tumor, other research seeks to identify why certain breeds of dogs seem to develop mast cell tumors more frequently than others.
Mast cell mediators include preformed molecules such as histamine and proteases stored in secretory granules (Kalesnikoff and Galli, 2008; Yamada et al.