cromolyn sodium

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Related to mast cell stabilizers: leukotriene modifiers

cromolyn sodium

[′krō·mə·lin ¦sōd·ē·əm]
(pharmacology)
C23H14Na2O11 An inhaled anti-inflammatory agent that prevents the degranulation of mast cells; effective in preventing bronchoconstriction.
References in periodicals archive ?
Allergic symptoms and signs following stent implantation need antihistamines, corticosteroids, and mast cell stabilizers. When symptoms persist, identification of the culprit with patch and/or prick skin tests and desensitization strategies should be applied.
He required regular medication including multiple antihistamines, mast cell stabilizers and oral steroids occasionally.
Out of other 25 patients taking oral antihistamine, nasal decongestants and mast cell stabilizers 50% showed good results, 35% showed satisfactory results and 15% showed poor results.
A 2004 systematic review of 40 RCTs (total N not provided) assessed the efficacy of topical treatment with mast cell stabilizers and antihistamines, comparing each with the other and placebo.
Comparative studies with sodium cromoglycate, a classical mast cell stabilizer, were also made.
Second-generation mast cell stabilizers work to prevent those cells from releasing the substances responsible for itching and, if chosen as allergy therapy, must be used regularly to prevent problems in people with seasonal allergic conjunctivitis.
Anti-allergy drops (eg, mast cell stabilizers) might also have been tried in cases where allergy is a factor.
He or she may recommend adjusting dosage levels or replacing corticosteroid therapy with alternative drugs such as leukotriene modifiers (Singulair; Zyflo), mast cell stabilizers (Crolom; Nasalcrom; Tilade), or the antibody Omalizumab (Xolair), which prevents the release of inflammatory chemicals that narrow the airways.
These categories include the following types of drugs: corticosteroids, beta-2 agonists, anticholinergic bronchodilators, methylxanthines, leukotriene modifiers, immunomodulators and mast cell stabilizers. The references to the NAEPP EPR3 guidelines in this article pertain to asthmatics 12 years of age and older.
It is in a class of medications known as mast cell stabilizers, which help control inflammation by preventing the release of inflammatory chemicals.
Other CFC-based medications include the corticosteroids triamcinolone and flunisolide, the mast cell stabilizers cromolyn and nedocromil, and the [beta]-agonists metaproterenol, pirbuterol, and combined albuterol-ipratropium.
In children, treatment with steroids, leukotriene inhibitors, and mast cell stabilizers have been shown effective.