He required regular medication including multiple antihistamines, mast cell stabilizers
and oral steroids occasionally.
Out of other 25 patients taking oral antihistamine, nasal decongestants and mast cell stabilizers
50% showed good results, 35% showed satisfactory results and 15% showed poor results.
A 2004 systematic review of 40 RCTs (total N not provided) assessed the efficacy of topical treatment with mast cell stabilizers
and antihistamines, comparing each with the other and placebo.
Comparative studies with sodium cromoglycate, a classical mast cell stabilizer
, were also made.
Second-generation mast cell stabilizers
work to prevent those cells from releasing the substances responsible for itching and, if chosen as allergy therapy, must be used regularly to prevent problems in people with seasonal allergic conjunctivitis.
As noted in the previous article (OT, November 12 2010), the ideal management of CLPC involves discontinuation of contact lens wear followed by a four-times-daily (QDS) regimen of a mast cell stabilizer
such as sodium cromoglicate.
Tablets, liquids, drops GuaifedPD, EntexLA, Over-the- DuraVENT, Exgest LA, counter Respaire (guaifenesin/ pseudoephedrine) Sinuvent (guaifenesin), Sudafed (pseudoephedrine/ phenylephrine HCL) Mast cell stabilizers
For patients who have allergic causes of nasal congestion, there are two general treatment options: (1) avoidance and environmental control and (2) pharmacotherapy with antihistamines, antihistamine/decongestant combinations, corticosteroids, mast cell stabilizers
, and immunotherapy.
Topical & injectable corticosteroids, NSAIDs, mast cell stabilizers
, histamine receptor blockers, and vasoconstrictors, immune modulators like tacrolimus eye ointment can been used alone or in combination.
Combination mast cell stabilizers
and antihistamines are the most recently developed drugs of those available for topical ophthalmic treatment of allergic conjunctivitis.
22) These mast cell stabilizers
should reduce mast cell degranulation in a dose-dependent fashion, (23) and may also reduce migration of white blood cells.