mastocytosis


Also found in: Dictionary, Medical, Wikipedia.

mastocytosis

[¦mas·tə‚sī′tō·səs]
(medicine)
Excessive mast cell proliferation. Also known as mast-cell disease.
Mentioned in ?
References in periodicals archive ?
In the 2008 World Health Organization classification system, the category of MPNs includes chronic myelogenous leukemia; chronic neutrophilic leukemia; polycythemia vera; primary myelofibrosis; essential thrombocythemia; chronic eosinophilic leukemia; mastocytosis; and MPN, unclassifiable; and the clinical and pathologic findings may overlap with the category of myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1.
Stephanie Brown, aged 11 months, with one of the rarest medical conditions in the UK - Diffuse Cutaneous Mastocytosis - and sitting pretty now after her treatment |
Sevoflurane is a preferable clinical choice in patients diagnosed to have mastocytosis, a group of rare disorders caused by the presence of too many mast cells and CD34+ mast cell precursors, without inducing mast cell degranulation [12].
Key words: mast cell, mastocytosis, neoplasia, self-mutilation, avian, psittacine bird, lovebird, Agapornis personata
"Although she's not cured of cutaneous mastocytosis there's been such a huge improvement in the appearance of her skin."
A bone marrow biopsy demonstrated systemic mast cell disease involving 5 to 10% of a hypercellular bone marrow and a diagnosis of systemic mastocytosis was made.
Thus far, several conditions, such as mastocytosis, left parotid gland excision, spinal anesthesia, laparoscopic ileocecal excision for cecal cancer, Takotsubo syndrome, coronary artery bypass graft, have been associated with the occurrence of Kounis syndrome during anesthesia and with the variety of drugs used for anesthesia.
The presence of a hyperpigmented skin lesion that becomes pruritic, raised, and erythematous when rubbed (Darier sign) is the major criterion for the diagnosis of cutaneous mastocytosis. (1) Minor criteria include a skin biopsy demonstrating a 4- to 8-fold increase in the number of mast cells within the papillary dermis and the presence of cKIT mutations.
Uncontrolled mast cell activity has been designated as MCAS since 2010; its behavior is much like mastocytosis except there is not an unusually high number of mast cells, just excessively activated mast cells.
Blueprint Medicines announced updated data from the ongoing, registration-enabling EXPLORER trial of avapritinib in patients with systemic mastocytosis. The updated data showed a confirmed overall response rate of 77% in advanced SM patients, as assessed by a central review committee of SM clinical experts.
In neonates or young infants with bullous lesions, other conditions such as herpes simplex infection, epidermolysis bullosa, bullous pemphigoid, linear IgA bullous dermatosis, bullous mastocytosis, and bullous erythema multiforme should be considered in the differential diagnosis.
Global Banking News-April 9, 2019-GT Biopharma passes IRB & CPRC approvals to launch human Phase 1 clinical trial of GTB-3550 for AML, MDS and mastocytosis