The low progesterone concentration in the late luteal phase was the cause of mastodynia, mastalgia and PMS in our subjects with FBD.
Even the slightest disturbance of the E2/P ratio may contribute to the occurrence of FBD with clinical manifestations of mastalgia and mastodynia, and its correction may improve the quality of life, reduce the frequency of surgical treatments and eventually, the potential risk of developing breast carcinoma.
In the early studies, where the effect of VAC on mastodynia
(Dickerson et at.
Wilson MC, Sellwood RA (1976) Therapeutic value of a supportive brassiere in mastodynia
. British Medical Journal 2: 90.
Clinically, there were significant improvements of mastodynia
(p0.004), tremor (p=0.048), and restless leg (p0.009) (Table 3).
Klein said that vitex, from the chaste tree, appears from German evidence-based studies to be effective for premenstrual symptoms, mastodynia
, and hyperprolactinemia.
Allevation of mastodynia
and the pre-menstrual syndrome with an extract of Lycopus europaeus (Thyreo-gutt).
Many premenstrual syndromes, particularly premenstrual mastalgia (mastodynia
) are associated with latent hyperprolactinemia (Jarry et al., 1994; Wuttke et al., 2003; Jarry et al., 1999).
Clinical and laboratory studies have indicated that the dried chaste-berry extract might be effective in treating PMS symptoms, abnormal menstrual cycling, mastodynia
, and hyperprolactinemia, which have all been linked to increased levels of prolactin (Berger et al.
(mastalgia) is beneficially influenced by an AC extract.