Only a few studies have reported alterations in urine levels of matrix metalloproteinases
and tissue inhibitor of metalloproteinases in patients with type 1 diabetes mellitus and these studies have conflicting results.
(MMPs) are special class of proteases that are categorized in five groups as per their substrate specificity: collagenases (MMP-1, -8 and -13), gelatinases (MMP-2 and -9), stromelysins (MMP-3, -10, and -11), matrilysins (MMP-7) and membrane-type (MMP-14 to -17, -24 and -25).
[1.] Nagase H, Visse R, Murphy G (2006) Structure and function of matrix metalloproteinases
(MMPs), extracellular-degrading proteases, contribute to metastatic and invasive cancer cells properties; their expression (particularly MMP-9 and MMP-2) is increased in carcinomas (Stamenkovic, 2000) MMPs activity can be specically inhibited by a group of structurally related, endogenous inhibitors known as tissue inhibitors of metalloproteases (TIMPs) (Al-Olayan et al., 2014).
Presence of matrix metalloproteinases
and tissue inhibitor of matrix metalloproteinase
in human sperm.
The matrix metalloproteinases
(MMPs) play an important role in the process of cardiac remodeling by regulating structural integrity of the extracellular matrix. MMP-2 is one of the predominant MMPs expressed in the cardiac ventricles.
Biochemical evidence indicates that serum proteinases, namely, matrix metalloproteinases
(MMPs), play key roles in the pathophysiology of this malignancy.
Ismail, "Elevated serum matrix metalloproteinase
9 (MMP-9) concentration predicts the presence of colorectal neoplasia in symptomatic patients," British Journal of Cancer, vol.
Hughes et al., "Aggrecanase versus matrix metalloproteinases
in the catabolism of the interglobular domain of aggrecan in vitro," Biochemical Journal, vol.
Rosenberg, "Diverse roles of matrix metalloproteinases
and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia," Neuroscience, vol.
The diagnostic value of matrix metalloproteinase
9 (MMP-9) and tissue inhibitor of matrix metalloproteinases
1 (TIMP-1) determination in the sera of colorectal adenoma and cancer patients.
Benhamou, "Matrix metalloproteinases
and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing," Diabetic Medicine, vol.