Furthermore, previous studies  have pointed out that the structural change of the medial frontal gyrus
in schizophrenia is correlated with the course of disease.
T Z p (unc) X 7 z Label 3.72 3.22 <0.001 4 -88 6 Cuneus BA18 (R) 5.21 4.13 <0.0001 2 56 -6 Medial frontal gyrus
(R) 5.00 4.01 <0.0001 60 -60 26 Superior temporal gyrus (R) 4.66 3.82 <0.0001 24 -34 72 Postcentral gyrus (R) 3.74 3.24 <0.001 44 -34 58 3.60 3.14 <0.001 22 -4 66 Superior frontal gyrus (R) 4.51 3.73 <0.0001 4 26 50 Superior frontal gyrus, frontal sup medial (R) 4.22 3.55 <0.001 -42 32 -2 Left inferior frontal gyrus (L) 4.15 3.49 <0.001 10 -76 -28 Cerebellum crus1 (R)
(b) Common regions of the correlated [sup.18]F-FDG and [sup.11]C-pPIB components, including bilateral medial frontal gyrus
, temporal lobe, and right insular lobe.
VMHC: voxel-mirrored homotopic connectivity; MeFG: medial frontal gyrus
; r: Spearman's correlation coefficient.
Eight significant clusters were found with increased brain activation from pre- to post-training, compared with non-CRT patients [Table 2] and [Figure 2], (1) the left inferior frontal gyrus (1120 mm [sup]3, BA9); (2) the left medial frontal gyrus
(512 mm [sup]3, BA32); (3) the right middle frontal gyrus (464 mm [sup]3, BA6); (4) the left precentral gyrus (416 mm [sup]3, BA6); (5) the right postcentral gyrus (416 mm [sup]3, BA2); (6) the left medial frontal gyrus
(352 mm [sup]3, BA6); (7) the right sub-gyral (296 mm [sup]3, BA6); and (8) the left sub-gyral (216 mm [sup]3, BA6).
In our study, Joint-Source 15 from the SBM analysis showed differences in the brains of schizophrenic and healthy volunteers in the middle frontal gyrus, precentral gyrus, subgyrus, postcentral gyrus, superior frontal gyrus, medial frontal gyrus
, cingulate gyrus, and superior temporal gyrus.
Consistent findings have been reported in healthy and clinical populations, describing the increase in the BOLD response when aversive affective faces are compared to neutral faces, mainly in the amygdala; frontal regions such as the superior frontal gyrus, medial frontal gyrus
, orbitofrontal cortex, and ventromedial cortex; temporal regions including the superior and medial temporal gyrus; other regions such as the fusiform gyrus, insula, anterior cingulate, among other structures [8-11].
A recent Spanish functional magnetic resonance brain imaging study demonstrated that schizoaffective disorder exhibits features that more closely resemble those of bipolar disorder than schizophrenia, including the finding that patients in clinical remission show failure of deactivation in the medial frontal gyrus
, compared with healthy controls, Dr.
In the MET group, metabolism was significantly (P < 0.005, uncorrected, k > 150) lower in the parahippocampal gyrus (PH) of the left limbic lobe, the fusiform gyrus (FG) of the left temporal lobe (Brodmann area 37), and the ventromedial prefrontal cortex (VMPFC), including foci in the right orbital gyrus (Brodmann area 11), left rectal gyrus (Brodmann area 11), and right medial frontal gyrus
(Figure 1(a)) than in the noMET group.
* Identified cluster Fractional anisotropy value Patient group Controls Right medial frontal gyrus
0.26 [+ or -] 0.01 0.29 [+ or -] 0.01 Right subgyral frontal lobe 0.27 [+ or -] 0.02 0.31 [+ or -] 0.02 Right subgyral temporal lobe 0.29 [+ or -] 0.02 0.32 [+ or -] 0.02 Left medial frontal gyrus
0.31 [+ or -] 0.02 0.34 [+ or -] 0.02 Left middle frontal gyrus 0.27 [+ or -] 0.02 0.30 [+ or -] 0.03 Left cingulate gyrus 0.38 [+ or -] 0.03 0.42 [+ or -] 0.03 Identified cluster t Test Right medial frontal gyrus
-5.98 Right subgyral frontal lobe -5.25 Right subgyral temporal lobe -4.70 Left medial frontal gyrus
-4.65 Left middle frontal gyrus -4.54 Left cingulate gyrus -4.38 * p = 0.001.
Boche and her team quantified Abeta-42--the plaque-forming length of the Abeta peptide--and phosphorylated tau in six brain areas affected by Alzheimer's pathology: the superior and middle temporal gyrus, medial frontal gyrus
, inferior parietal lobule, entorhinal cortex, and subiculum and CA1 regions of the hippocampus.