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Related to Megacolon: toxic megacolon


Hypertrophy and dilation of the colon associated with prolonged constipation.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



in man, enlargement of part or all of the colon.

Megacolon usually originates with congenital immaturity of the colon’s innervation apparatus. The clinical course of the condition is characterized by persistent constipation beginning in the first years (sometimes in the first months) of life. This, the most common form of megacolon, is called Hirschsprung’s disease. In adults, megacolon may be caused by the presence of mechanical obstructions (tumor, cicatricial stenosis). Treatment is surgical.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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Severe, non-responsive cases of constipation may progress to megacolon and obstipation (a condition characterized by permanent loss of function of affected colon).
Observation of effect of Laparoscopic modified Soave procedure in the treatment of neonatal congenital megacolon. Med Healthcare Apparat.
quoted ICC in circular muscle coat in control group as 24.6 11.9 and 32.1 13.7 and in longitudinal muscle coat 15.1 7.9 and 3.6 2.4 whereas in megacolon they quoted 10.0 6.8 and 8.4 7.5 in circular muscle and 4.8 2.8 and 1.1 1.0 in longitudinal muscle coat.10 Their results showed obvious statistically decreased number of ICC in inner circular and outer longitudinal muscle coats when compared megacolon group with control group.11 The proportions of mature ICC in the narrow segment (0.059 0.099%) of HD colon were significantly reduced when compared to their proximal segment (1.144 0.173) in adult normal colon.12
In the chronic phase, the central nervous, gastrointestinal, and cardiovascular systems are affected in 10% to 30% of infected people, and peripheral neuropathy, cardiomyopathy, megacolon, or megaesophagus may be observed.
The chronic infection may manifest itself as indeterminate or symptomatic, and 20-30% of Chagas patients develop cardiomyopathy, megaesophagus, or megacolon. (3) Nevertheless, the disease may seriously affect transplant recipients, cancer patients, and individuals living with AIDS due to immunosuppression.
difficile) is a spore-forming pathogen that typically causes symptoms in individuals with altered gut microbial flora, releasing toxins that can result in a range of disease manifestations from asymptomatic colonization to diarrhea, pseudomembranous colitis, toxic megacolon, intestinal perforation, or, in the most severe cases, death.
Os exames bioquimicos demonstraram alteracoes (Hemoglobina: 7,3 g/dl; Hematocrito: 22,2%; Leucocitos = 2.880mm3; B = 40%; Plaquetas = 81.200 mil/mm3; Sodio = 132 mEq/L; Potassio = 2,3 mEq/L; Creatinina = 1,1mg/dL; Ureia = 50 mg/dL; PCR = 58,2 mg/l, albumina 3,0 g/L, realizou-se RX abdominal em ortostase constatou distensao de alca sem criterios para megacolon toxico, a Gasometria arterial: acidose metabolica e Eletrocardiograma: alteracao difusa da repolarizacao ventricular.
In an immunocompromised patient, CMV infection of colon can present in a variety of ways: ulcers, proctocolitis, pseudotumors, pseudomembranes, appendicitis, perforation, pneumatosis intestinalis, or toxic megacolon [1].
Complications range from rare intestinal complications of toxic megacolon, intestinal obstruction to systemic complications of hypovolemia, seizures, hyponatremia, and leukemoid reaction.
The clinical spectrum of Clostridium difficile infection (CDI) can range from benign gastrointestinal colonization to mild diarrhea and life threatening conditions such as pseudomembranous colitis and toxic megacolon. Extraintestinal manifestations of C.
Only few PTHS patients have comorbidity for Hirschsprung's disease (HSCR) characterized by the absence of enteric ganglia along a variable bowel length (congenital aganglionic megacolon) [1].