megakaryocyte


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megakaryocyte

[¦meg·ə′kar·ē·ə‚sīt]
(histology)
A giant bone-marrow cell characterized by a large, irregularly lobulated nucleus; precursor to blood platelets.
References in periodicals archive ?
Chemotherapy-Induced thrombocytopenia derives from the selective death of megakaryocyte progenitors and can be rescued by stem cell factor.
We speculate that the unfavourable response to splenectomy in patients with steroid-resistant disease is possibly due to greater megakaryocyte dysfunction, in addition to increased peripheral consumption.
4, A-C, individuals with EMV mRNA recovery by day 15 all showed data points above this 45[degrees] dotted line, indicating that EMV mRNA recovery was earlier than that for CBC for all 3 lineages, myeloid, erythroid, and megakaryocyte.
The second, collectively described as myeloid, generates red cells or the erythron, granulocytes and monocytes as well as megakaryocytes from which platelets will ultimately be derived (Fig.
2) This increase in the platelet peripheral blood count has been associated with bone marrow megakaryocyte hyperplasia and the increased risk of thrombotic and hemorrhagic complications.
This reduction can be induced by either a reduced production of thrombocytes (suggesting dioxin toxicity at the megakaryocyte level in the bone marrow) or an increased sequestration of ineffective platelets (suggesting toxicity at the gene level).
The drug, megakaryocyte growth development factor or MGDF, was being tested in cancer patients receiving chemotherapy.
This normal bone marrow contains a great variety of cells indifferent stages of maturation: red cell precursors, white cell precursors and the very large cell, called a megakaryocyte, which manufactures the platelets.
The SBIR Contract funds the development of CLT-009, a first-in-class, human allogeneic Megakaryocyte Progenitor Cell therapy for the treatment of thrombocytopenia in cancer patients and allows the Company to conduct studies to enable an Investigational New Drug (IND) Application to be filed with the FDA in the next two years.
5 The findings of hypercellularity (95%) and megakaryocyte hyperplasia can also be seen in the index case.
Other features noted in bone marrow in HIV patients include numerous bare megakaryocyte nuclei, polymorphic lymphoid aggregates, gelatinous degeneration, deteached nuclear fragments in granulocytes and giant metamyelocytes in the absence of megaloblastosis.