Gorelashvili et al., Megakaryocyte
volume modulates bone marrow niche properties and cell migration dynamics.
Mechanisms causing thrombocytopenia have been suggested, which are increased platelet destruction and impaired platelet production by megakaryocytes
in the bone marrow mediated by autoantibodies in the peripheral circulation.
TPO is a very important regulatory factor for the megakaryocyte
proliferation, differentiation, and maturation and platelet production.
(b) As for megakaryocyte
counts in ITP patients, no significant correlation was found among the three genotypes (p = 0.085).
When evaluating megakaryocyte
maturity by cellular morphology, the 8N polyploidy was observed in both SI-treated and ABI-treated MK-PROs.
Interestingly, previous experiments performed with different oxidase inhibitors suggest that the NADPH oxidase enzyme is the critical source of ROS in megakaryocytes
 and that NADPH oxidase inhibition completely prevents the signaling cascade activation required for megakaryocyte
differentiations , reducing their polyploidization .
From precursor to product: how do megakaryocytes
ploidy and platelet changes in human diabetes and atherosclerosis.
Comparison of the diagnostic accuracy of the MSLN gene products, mesothelin and megakaryocyte
potentiating factor, as biomarkers for mesothelioma in pleural effusions and serum.
More recently, recognising that platelet underproduction and megakaryocyte
dysfunction play a substantial role in the pathophysiology of ITP, TPO receptor agonists such as romiplostim and eltrombopag have become available.
(7-9) It is generally accepted that thrombocyte volume is determined during the production of thrombocytes from megakaryocytes
. (10) It is believed that large thrombocytes are younger (11) and less reactive.
The mRNAs included control housekeeping genes [actin, beta (ACTB)  and beta-2-microglobulin (B2M)] and myeloid [defensin, alpha 3, neutrophil-specific (DEFA3) and serglycin (SRGN)], erythroid [hemoglobin, beta (HBB) and uroporphyrinogen decarboxylase (UROD)], and megakaryocyte
[integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) (ITGA2B) and integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ITGB3)] lineage-specific genes.