The basic investigation in the suspected cases of megaloblastic
anaemia with pancytopenia include complete blood counts, peripheral blood film examination, reticulocyte count and cobalamin and folate assay.
A role for homocysteine increase in haemolysis of megaloblastic
anaemia due to vitamin B12 and folate deficiency: results from an in vitro experience.
Deficiency of Vitamin B12 or folic acid can lead to megaloblastic
anemia due to impaired DNA synthesis due to Vitamin B12 and/or folic acid.
In general, increases in Hb [A.sub.2] due to NRTI (or megaloblastic
anemia) are less than that seen in beta thalassemia trait.
anaemia###01 (6.25%)###0 (0%)###0 (0%)###01 (1.75%)
Acute leukemia was the commonest finding 32.2%, followed by aplastic anemia 30.8%, megaloblastic
anemia 13.2% and miscellaneous findings.1 In another retrospective descriptive study 205 patients age between 6 months and 14 years were identified with diagnosis of pancytopenia.
Although vitamin [B.sub.12] deficiency is known to cause megaloblastic
anemia, our patient had an MCV within the reference interval, a slight increase of RDW-CV of 18.0%, and hemoglobin (Hb) within the reference interval at 13.6 g/dL.
The classic hematological finding in pernicious anemia consists of megaloblastic
anemia, characterized by macrocytosis and hypersegmented neutrophils on peripheral smear .
The bone marrow was hypercellular and was supporting the diagnosis of megaloblastic
Abdominal USG, cranial and spinal MRIs were normal and blood smear findings were consistent with megaloblastic
Other notable signs of anaemia include paleness of skin and mucous membrane Specific features are related to specific causes such as koilonychia in iron deficiency, atrophic glossitis in megaloblastic
changes especially in the myeloid series, plasma cell, marked increase in the number of hystiocytes and a high number of hemofagocytes were observed on bone marrow aspiration biopsy which was performed on the second day of hospitalization because of bicytopenia.