melanocyte


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melanocyte

[mə′lan·ə‚sīt]
(histology)
A cell containing dark pigments.
References in periodicals archive ?
These precursor cells also have potential applications in research on melanoma, melanocyte disorders and aging-related skin hue changes.
Melanocytes are the cells at the roots of our hair that create melanin, or our hair color.
MITF is best known for its role in regulating the many functions within melanocytes. However, the researchers found that MITF also serves to keep the melanocytes' interferon response in check.
KIT is a type III receptor tyrosine kinase that binds to the ligand MGF and plays a crucial role in the growth and differentiation of melanocytes, hematopoietic cells, and germ cells.
Some of the activating mutations encode nonfunctional rather than functional proteins and these nonfunctional proteins account for the overexpression of cKit receptor; and not all gain-of-function mutations result in dysregulated increased melanocyte proliferation and survival.
Abbreviations Ad: Adenovirus DP: Dermal papillae HF: Hair follicle IRS: Inner root sheath ORS: Outer root sheath sFRP4: Secreted frizzled-related protein 4 sHG: Second hair germ McSC: Melanocyte stem cell TRP1: Tyrosinase-related protein 1 TRP2: Tyrosinase-related protein 2 TYR: Tyrosinase Wnt: Wingless-type MMTV integration site family X-gal: 5-Bromo-4-chloro-3-indolyl-[beta]-D-galactoside.
To further characterize the mechanisms by which compound 1 increases melanocyte pigmentation, a cell-free mushroom tyrosinase assay was performed.
In vertebrates, pigment-producing cells called melanocytes migrate around the body as the embryo develops.
Vitiligo is a patchy loss of skin pigmentation caused by destruction of the pigment- producing cells called melanocytes," said Dr Mohanty.

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