melanocyte-stimulating hormone


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Related to melanocyte-stimulating hormone: oxytocin, melanocyte-stimulating hormone (MSH)

melanocyte-stimulating hormone

[mə′lan·ə‚sīt ¦stim·yə‚lād·iŋ ′hȯr‚mōn]
(biochemistry)
A protein substance secreted by the intermediate lobe of the pituitary of humans which causes dispersion of pigment granules in the skin; similar to intermedins in other vertebrates. Abbreviated MSH. Also known as melanophore-dilating principle; melanophore hormone.
References in periodicals archive ?
A missense mutation in the gene for melanocyte-stimulating hormone receptor (MCIR) is associated with the chestnut coat color in horses.
* The report provides a snapshot of the global therapeutic landscape for Melanocyte-Stimulating Hormone Receptor (Melanocortin Receptor 1 or MC1-R or MC1R or MSHR)
Targeted photo-thermal ablation of murine melanomas with melanocyte-stimulating hormone analog-conjugated hollow gold nanospheres.
With respect to skin, there are sections on hairiness and hypertrichosis, baldness and testosterone, piebaldism, albinism, skin colour, red hair (and the polymorphisms of the melanocyte-stimulating hormone receptor, MC1R, which cause red hair), and finally supernumerary breasts.
Stimulation of melanocyte-stimulating hormone receptors by retinoic acid.
When the MCIR receptor is bound by its agonist, alpha melanocyte-stimulating hormone ([alpha]-MSH), the intracellular levels of cyclic adenosine monophosphate (cAMP) are elevated through a G-protein signaling pathway and the black/brown eumelanin is produced [18].
This is an analogue of a melanocyte-stimulating hormone. A randomized study conducted at two academic medical centers found that the combination of afamelanotide implant and narrow-band UVB phototherapy resulted in superior and faster repigmentation, compared with narrow-band UVB alone (JAMA Dermatol.
Bremelanotide, which is a melanocortin agonist (a compound which binds to a cell receptor and triggers a response) drug candidate, is a synthetic peptide analog of the naturally occurring hormone alpha-MSH (melanocyte-stimulating hormone).

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