In the papillary and upper reticular dermis, dendritic melanocytes are present and surrounded by fibrous sheaths (which are not present in other dermal melanocytosis
, such as blue nevus or mongolian spots).
Association of ocular and oculodermal melanocytosis
with the rate of uveal melanoma metastasis: analysis of 7872 consecutive eyes.
b) Iris melanocytosis
which is not associated with increased risk of developing a uveal melanoma
In actinic melanocytosis
, large melanocytes may extend more deeply or symmetrically in the follicular infundibula and acrosyringia.
Congenital ocular melanocytosis
predisposes to uveal melanoma, as well as melanoma of the ipsilateral skin, orbit, optic nerve head and brain.
Dilatation of capillaries and connective tissue disintegration, elastosis, hemosiderin deposition, melanocytosis
, and abundance of inflammatory cells are all seen in the dermis.
Their spectrum varies from benign to malignant and includes leptomeningeal melanocytosis
, melanocytoma to its overtly malignant counterpart melanoma.
Blue nevus, also known as pigmented melanocytosis
or prostatic pigmentary nevohyperplasia, is the most frequently reported pigmented lesion with 28 cases reported to date.
Why should congenital oculodermal melanocytosis
be referred to ophthalmology?
is a congenital, unilateral condition involving hyperpigmentation of the uveal tract and episclera.
Lifetime prevalence of uveal melanoma in white patients with oculo(dermal) melanocytosis
In a large clinical series, (5) 8 of 4500 patients presented with bilateral melanoma; no specific syndrome was identified other than ocular melanocytosis
for 2 patients.