melanoma


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Related to melanoma: Nodular melanoma

melanoma:

see skin cancerskin cancer,
malignant tumor of the skin. The most common types of skin cancer are basal cell carcinoma, squamous cell carcinoma, and melanoma. Rarer forms include mycosis fungoides (a type of lymphoma) and Kaposi's sarcoma.
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Melanoma

 

melanoblastoma; a malignant tumor that consists of melanin-producing cells.

Factors conducive to the development of melanomas include injury and hormonal stimulation, especially during puberty. Melanomas generally occur on the skin; less often, they appear on the retina, pia mater, nasopharynx, larynx, esophagus, and mucosa of the intestine and other organs. Melanomas usually develop at the site of pigmented or depigmented birthmarks, but they may also appear elsewhere. The process starts with a barely perceptible, painless tumor on the skin, sometimes resembling a wart, which gradually becomes dark brown or black. Occasionally, it ulcerates and bleeds. In case of injury, the tumor may enlarge quickly and become tuberous, dense at the base, and stiffer. The regional lymph nodes enlarge. The initial signs that a melanoma is developing at the site of a birthmark are the birthmark’s enlargement, an intensification or reduction in its pigmentation, and the appearance of a red rim around it. Treatment involves prompt surgical intervention, based on early diagnosis, and the use of radiotherapy and drugs to retard the growth and reproduction of the cells.

I. IA. SHAKHTMEISTER

melanoma

[mel·ə′nō·mə]
(medicine)
A malignant tumor composed of anaplastic melanocytes.
A benign or malignant tumor composed of melanocytes.

melanoma

Pathol a malignant tumour composed of melanocytes, occurring esp in the skin, often as a result of excessive exposure to sunlight
References in periodicals archive ?
The researchers found a decrease in the median Breslow thickness from 0.90 mm for the first melanoma to 0.65 mm for the second melanoma.
Using a newly expanded performance cohort of 901 archival cutaneous melanoma samples (211 of which were not previously reported) from 22 centers, the analysis was designed to examine whether incorporating the DecisionDx-Melanoma test result in treatment decisions improves upon traditional melanoma staging methods.
We have recently set up a melanoma research group at the Highlands and Islands University in Inverness, thanks to funding support from Highlands and Islands Enterprise.
Preliminary data from Provectus' uveal melanoma expansion cohort of its Phase 1 "basket study" of PV-10 for the treatment of cancers metastatic to the liver were presented in a poster presentation at the 15th International Congress of the Society for Melanoma Research (SMR 2018 Congress) in late-2018: a total of four patients had received PV-10 for at least one uveal melanoma liver tumor, two patients had received a second round of PV-10 treatment to an additional liver tumor, and one patient initiated standard of care immunotherapy (Opdivo + Yervoy) between PV-10 treatments; treatment-related adverse events were consistent with established patterns; and, tumor reduction was observed in 5 of 6 PV-10-injected tumors.
Of note, S100 immunostaining was performed and supported the diagnosis of melanoma. In addition, an associated dermal melanocytic nevus consistent with what was seen on exam was identified histologically.
However, the guidelines make it clear that all patients whose family history includes melanoma should be counseled about their genetic risk.
It's also important to remember that childhood melanoma often doesn't follow the ABCDE (asymmetry, border irregularity, color not uniform, diameter greater than 6 mm, and evolution) signs of melanoma common in adults.
Melanoma is relatively rare and makes up 10% of all skin cancer cases.
Contained in the Guide was information on the ABCDE's of melanoma (Table 1).
Two international studies conducted by researchers at Melanoma Institute Australia have successfully prevented the disease from spreading in stage III patients who had had their tumour surgically removed.
Keywords: Diabetes, Diabetic foot ulcer (DFU), Melanoma.

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