melanophage


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melanophage

[mə′lan·ə‚fāj]
(histology)
A phagocytic cell which engulfs and contains melanin.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The dendritic component is often more pigmented than the conventional component, and may be accompanied by prominent melanophages. Combinations of conventional and Spitz nevi can be particularly challenging because of the presence of a population of larger epithelioid cells mimicking melanoma.
On dark skin, the blue-gray Wickham striae and brownish globules correspond to dermal melanophages and epidermal melanocytes, respectively.
Histopathologically, the multiple blue-grey dots represent melanophages in the papillary dermis.3 This finding corresponds to the histopathological abnormalities found in lichen planopilaris and discoid lupus erythematosus resulting from interface dermatitis and the subsequent pigment incontinence.
Tumoral melanosis is a rare histopathological phenomenon characterized by confuent dermal nodular aggregates of heavily melanized polygonal cells consistent with melanophages. The initial occurrence of tumoral melanosis always raises the suspicion of a regressed melanocytic proliferation, especially a melanoma.
Histologically, Melanocytoma consisted of mixture of spindloid and epithelioid melanocytes with scattered melanophages. Neoplastic cells were small spindle and epithelioid shaped cells with intra cytoplasmic brown to black coloured melanin granules.
Dermoscopy of a lesion showed faint gray-blue to bluish small dots over a bluish background, corresponding to melanin-laden melanophages in deeper dermis (Tyndall effect) (Figure 4).
Upon histopathological examination, skin specimens of patients with GBFDE showed more eosinophil infiltration and more dermal melanophages. Lesional infiltrates in GBFDE had more dermal CD4+ cells including [Foxp3.sup.+] cells, less intraepidermal CD56+ cells, and fewer intraepidermal [granulysin.sup.+] cells compared to those in SJS/TEN.
Histologically, most of the melanophages are in the superficial and deep dermis.
The underlying dermis showed dense inflammatory infiltrate composed of lymphocytes, plasma cells and melanophages. There was no evidence of dermal invasion.
The histopathological features of LP-like GVHD patients included hyperkeratosis, focal increases in the granular cell layer, vacuolar changes of basal layer, scattered keratinocyte necrosis in the epidermis and melanophages, and a large number of lymphocytic infiltration in the dermis [Figure 2].{Figure 2}
Aspiration cytology of the subcutaneous nodules showed marked anisokaryosis, hyperchromatic and stippled nuclei, prominent nucleoli, intranuclear inclusions, and pigment laden melanophages (Figure 2a).
If taken from hyperpigmented macules, samples will show an increase in melanin in the basal layer, pigmentary incontinence, and some melanophages in the upper dermis [38].