We used a red chromogen for immunohistochemistry detection, thus, eliminating the possibility of false-positive staining of pigmented melanophages
or dendritic cells.
Other constant morphologic components in DPN are melanophages and a mild mononuclear inflammatory cell infiltrate.
Nests of melanocytes were surrounded by deeply pigmented melanophages.
Pigmented BN may also contain heavily pigmented melanophages, which feature abundant cyto plasm with large melanin granules and round or ovoid vesicular nuclei.
Many of these cells are tumor-associated melanophages.
Partially regressed melanomas most often present clinically as either variably pigmented or hypopigmented, flat lesions, a histologic picture of focal papillary dermal fibrosis, and a variably cellular infiltrate of melanophages and lymphocytes.
Microscopically, these lesions consist of nodular collections of dermal melanophages positive with CD68 and negative for melanocytic markers (S100, HMB-45, Melan-A).