(b) Indicates nominal significant deviation from expected Mendelian ratio
(P < 0.05).
MyD88 mice were born at the expected Mendelian ratio
. Among these independent lines, lines B and D were selected for further analysis based on comparable transgene expression levels, viability, and germline transmission.
The Mendelian ratio
was observed in all size classes of males and females (Figure 1), except the 7th (from 26 to 30 mm), in which females predominated (p=0.026).
Encouragingly, we observed viable [hth.sup.C1]/[hth.sup.CPT1000378] flies in expected Mendelian ratio
(Table 3), suggesting that [hth.sup.CPTI000378] retains at least some hth functions.
In addition, chi-square analysis revealed that 350 of those markers (179 in female and 171 in male) segregated with a 1:1 ratio, and 54 (30 in female and 24 in male) deviated significantly from the Mendelian ratio
at P < 0.05.
To determine whether a single male was unlikely to account for the genetic diversity of a female's brood, we used a significant deviation from a Mendelian ratio
among progeny genotypes as our criterion.
All segregating loci scored were checked with the chi-square test for goodness of fit to the 1:1 Mendelian ratio
. Distorted markers were included in mapping analysis for possible identification of regions of distortion.
The progeny of such plants are expected to show the typical 3:1 Mendelian ratio
of tolerant to sensitive plants for one gene, and 15:1 for two genes in the case of imidazolinone.
Chi-square ([chi square]) analyses, using the correction factor of Yates (Steel and Torrie, 1980), were performed to determine if the observed segregation ratio was consistent with a Mendelian ratio
In crosses where both parents carried B chromosomes, [k.sub.B] through the female was estimated by subtracting 0.5 per paternal B from the mean number of B chromosomes in the progeny (since the B was transmitted in a Mendelian ratio
through males) and dividing by the number of B chromosomes carried by the female parent.
In addition, the chi-square analysis revealed that 350 (179 in female and 171 in male) segregated with a 1:1 ratio and 54 (30 in female and 24 in male) deviated significantly from the Mendelian ratio
at P < 0.05.
The remaining four families do not fit any of the tested ratios and contain a large number of progeny in the RL negative/2-5A negative category, which would not be characteristic of any simple Mendelian ratio
. Larger sample sizes are needed to better determine the inheritance of RL and 2-5A relative to one another in the [T.sub.1] generation.