syphilis, symptomatic at the end of the first year of life, is characterized by hydrocephalus, cranial nerve paralysis, growth retardation, optic atrophy and seizures (2,7).
Neurosyphilis may occur early, being either asymptomatic or in the form of syphilitic meningitis, or late as meningovascular
syphilis, general paresis, or tabes dorsalis, a condition where the spinal column is affected.
pallidum infection, and while classic late syphilis manifested 5-25 years later in the pre-penicillin era, early meningovascular
syphilis may develop within months to years following infection.
Clinical presentation includes meningitis, meningoencephalitis, meningovascular
involvement, peripheral neuropathy, radiculopathy, and demyelinating disease.
Tercera fase, Meningovascular
, con dos formas clinicas: Cerebral y Espinal.
La sensibilidad es elevada en la sifilis meningovascular
y en la paralisis general progresiva, pero baja en la neurosifilis asintomatica y en los cuadros de tabes dorsal.
5,6) Neurosyphilis may be asymptomatic or symptomatic, manifesting in the latter as syphilitic meningitis, meningovascular
syphilis, or parenchymatous neurosyphilis.
How HIV may affect the course and treatment of syphilis * Higher RPR or T pallidum hemagglutination assay titer * False-negative syphilis serology * More frequent prozone phenomenon (* 68) * Higher rate of asymptomatic primary syphilis (66-68) * Multiple or deeper chancres during primary syphilis (69) * Overlap of primary- and secondary-stage features of syphilis (66,68) * Shorter latency period before meningovascular
syphilis * Increased rate of early neurologic and ophthalmic involvement (66,68) * More rapid progression to tertiary manifestations (69) * Reduced efficacy of standard therapy for early syphilis ([dagger] 66) * More frequent relapse ([dagger] 68,70) * Delayed normalization of CSF values after treatment (69) Adapted from Pialoux et al.
Experience of meningovascular
syphilis in human immunodeficiency virus infected patient.
Within five to ten years of an untreated initial infection, patients can develop meningovascular
To the best of our knowledge, only 3 cases of medial or mediolateral medullary infarction and the classic clinical features of central Tapia syndrome have been described during the past century; 2 of these patients had brainstem infarctions, and 1 had meningovascular
The first group had meningovascular
complications as prominent signs.