Author/Year/Title Confounders Effectiveness and Ulcerative colitis, adverse events of Mercaptopurine
, azathioprine in Methyltransferase inflammatory bowel levels disease: 9-year follow-up study Guerra et al, 2014 Adverse effects of Ulcerative colitis azathioprine in patients with inflammatory bowel disease (IBD) Estrada et al, 2014 Azathioprine in the Ulcerative colitis elderly--Is it Methyltransferase tolerated and is it safe?
Febuxostat is contraindicated in patients being treated with azathioprine, mercaptopurine
, or theophylline.
(13,15) Recently, mercaptopurine
has been also implicated in inducing a secondary malignancy.
Analysis of thiopurine S-methyltransferase polymorphism in the population of Serbia and Montenegro and mercaptopurine
therapy tolerance in childhood acute lymphoblastic leukemia.
In addition, the injection of Tp (inducer of [alpha]2M production) into infected rats led to an increased parasitaemia that reached its peak on the seventh day post-treatment (19% [+ or -] SD), while inhibition of [alpha]2M production by mercaptopurine
reduced the parasitaemia to 2-3% [+ or -] SD in the SI rats and to 23% [+ or -] SD in the CyI rats (Fig.
HSTCL has been reported in people treated with infliximab who also have been treated or were currently undergoing treatment with a thiopurine (azathioprine and mercaptopurine
), according to the manufacturer.
Background & objectives: Mercaptopurine
, azathioprine, and thioguanine, used as antineoplastic agents and immunosuppressants are catabolized by thiopurine methyltransferase (TPMT) enzyme, which exhibits genetic polymorphism.
First-Time Generics Introduced in 2004 * DOLLAR VOLUME DRUG COMPANY (in millions) Oxycodone HCI ER Teva $207.0 Bupropion HCI SR Watson 165.3 Glyburide/Metrofm Ivax 115.2 Burpropion HCI SR Eon 112.6 Gabapentin Greenstone 81.6 Carboplatin Sicor 75.0 Gabapentin Teva 65.1 Glyburide/Metrom Par 53.3 Gabapentin Alpharma 48.6 Mercaptopurine
Par 31.0 * Excludes branded generics.
Nova Laboratories, a United Kingdom-based pharmaceutical company, has received approval from The European Medicines Agency (EMA) for in-use shelf life extension of up to 56 days for Xaluprine, a liquid form of mercaptopurine
, according to reports yesterday.
However, febuxostat is contraindicated in patients who are taking azathioprine, mercaptopurine
, and theophylline.
has been given clearance for mercaptopurine
tablets USP, 50 mg.