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The simple squamous-cell epithelium lining the pleural, pericardial, peritoneal, and scrotal cavities.
The lining of the wall of the primitive body cavity situated between the somatopleure and splanchnopleure.



in vertebrates and man, the epithelial tissue that lines the serous membranes of the body cavity (peritoneum, pleura, pericardium).

Mesothelium is formed from mesoderm. It consists of a single layer of densely arranged flat polygonal cells. In lower vertebrates (cyclostomes, fish, amphibians), mesothelial cells are wholly or partly furnished with cilia. In mammals and man, the surfaces of the cells are covered with microvilli, which assist in the absorption and excretion of cavitary fluid. Mesothelium is highly sensitive to external influences. When the serous membranes are irritated and an inflammatory reaction results, the continuity of the mesothelial layer is interrupted, the cells are destroyed, and the underlying connective tissue is exposed. The connective tissue cells then penetrate the irritated area and phagocytize the dying tissue areas and, in septic inflammation, the bacteria. The connective tissue then proliferates, demarcating the focus of irritation and forming adhesions. Mesothelium grows over the adhesions, preventing them from further development and preventing visceral concrescence.

References in periodicals archive ?
Differentiation of bone marrowderived cells into regenerated mesothelial cells in peritoneal remodeling using a peritoneal fibrosis mouse model.
Reactive mesothelial blocks were entrapped within fibrous tissue, with retraction artifact (Figures 7(b) and 7(c)).
Peritoneal healing differs from other epithelial tissues healing, where during the peritoneal healing process, the reepithelialization of peritoneal surfaces occurs simultaneously throughout the surgical site, as mesothelial cells migrate into the supportive matrix and would initiate multiple sites of healing.
[13] CD10+, PSA- orifice, 3 cm Zamecnik and Epithelium: Within Hostakova [14] ER+, PR+, mesothelial CK5,6,7+, cyst of calretinin+, tunica EMA+ Stroma: vaginalis; PR+, 4 mm focus calretinin+, of endometriosis CD10+ found in 7 mm cyst Scully [15] Not reported Scrotum Scully [15] Not reported Scrotum Present CK7+, ER+, Right vas case CD10+, CD15+, deferens, GATA-3- 9.0 x 5.6 x 5.3 cm Source Treatment Followup Beckman Not Not et al.
Although positive, WT1 is the least reliable immunostain for mesothelial cells as serous carcinomas can also express the protein [13] whereas vacuolated cells and thread-like bridges are actually characteristic and supportive of the diagnosis of adenomatoid tumors [5, 15].
BMPM was first described in 1928 by Plaut, who incidentally observed some pelvic cystic lesions during surgery for uterine leiomyoma [16], but its mesothelial nature was identified in 1979 by Mennemeyer and Smith [17].
Piche, "Role of malignant ascites on human mesothelial cells and their gene expression profiles," BMC Cancer, vol.
Here, we investigated its influence on epithelial-mesenchymal transition (EMT) of rat peritoneal mesothelial cells (PMCs) in vitro induced by a high-glucose (HG) culture solution.
CA125 is a glycoprotein secreted from mesothelial cells.
There were two false positives for RTPCR, one with pleural mesothelioma and the other with chronic pleuritis with mesothelial hyperplasia.
Pericardial cysts are defined as unilocular, fluid-filled masses that arise from the mediastinal fat, with walls composed of connective tissue and a single layer of mesothelial cells.
There is evidence for BAP1 activity in the cytoplasm, and normal mesothelial cells may show nuclear and weaker cytoplasmic labelling [21, 34]; but cytoplasmic labelling in isolation indicates mutated inactive BAP1.