meta-analysis


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meta-analysis

a method by which the results of a number of quantitative studies can be analysed together to produce an overall impression from a field of research. This method lays emphasis on EFFECT SIZE as well as providing a SIGNIFICANCE TEST for the results. It has advantages over a conventional review in that it forces the analyst to evaluate the method and the results of a study more critically and that it provides an objective method for synthesizing the results from such studies. There are two basic approaches to meta-analysis. The first and most common approach involves combining the results from the studies in order to produce a single effect size, inferential statistic and probability. The second approach involves comparing studies which differ over some aspect of their method to see if the results of studies which utilized one design or measure differ from the results of studies employing a different design or method. By combining the results of a number of studies, meta-analysis can circumvent the problems of low STATISTICAL POWER which may characterize the individual studies. (See Cooper; 1998; Cooper and Hedges, 1994; Rosenthal, 1991)
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The authors performed a meta-analysis to investigate garlic's effect on BP.
Meta-analysis requires that individual investigations report sufficient statistical results in their findings.
The meta-analysis included 2,399,200 persons and 25,618 cataracts.
He and his colleagues conducted a systematic review and meta-analysis of 15 studies evaluating the effects of metformin, TZDs, sulfonylureas, and insulin on colorectal cancer risk.
Meta-analysis was applied to calculate the summary relative risk and their 95% confidence intervals.
The topics covered can be categorized as (a) intrinsic limitations of meta-analysis, (b) unfortunate experimental practices in parapsychological research, (c) problematic properties of the experimental findings in parapsychology, and (d) unfortunate meta-analysis practices in parapsychology.
The meta-analysis, which included 40 published studies and 56,111 women with breast cancer, found no association between risk of the malignancy and circulating serum insulin level, insulin growth factor-1 level, fasting blood glucose level, or C-peptide concentration.
In contrast, when the IARC Working Group for Volume 98 reviewed the evidence on shift work and cancer, a published meta-analysis had reported a statistically significantly increased risk for breast cancer among women who regularly worked the night shift (Megdal et al.
The two most commonly used antiviral drugs for treating influenza infections, oseltamivir and zanamivir, each provide a net benefit to patients compared with no treatment, concluded the authors of a meta-analysis of 74 influenza antiviral observational studies.
According to the company, the first meta-analysis combined raw data from four double-blind trials into an Individual Participant Data Meta-Analysis (IPDMA).
The meta-analysis determined that those choosing to follow a vegetarian diet had a 27% lower risk of developing diabetes than did non-vegetarians.