Acidosis

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acidosis

[‚as·ə′dō·səs]
(medicine)
A condition of decreased alkali reserve of the blood and other body fluids.

Acidosis

 

a change in the acid-alkaline balance of the organism as a result of insufficient removal and oxidation of organic acids (for example, beta-hydroxybutyric acid). Usually these products are rapidly removed from the body. In febrile diseases, intestinal disorders, pregnancy, starvation, and such, they are retained in the body; this is manifested in mild cases by the appearance of acetoacetic acid and acetone in the urine (so-called ketonuria). In severe cases (for example, diabetes mellitus) it may lead to coma. Treatment consists of removal of the cause of acidosis (for example, by administering insulin in case of diabetes); there is also symptomatic treatment—soda and an abundance of fluids taken internally.

References in periodicals archive ?
This last step is very slow thus resulting in accumulation of formic acid in the body which leads to life threatening metabolic acidosis. Another postulated mechanism is the low hepatic levels of these enzymes in humans leading to methanol intoxication.
An integrative view of findings at the start of the first dialysis of the week showed slight acidemia (mean pH 7.32 [+ or -] 0.05), mean bicarbonate concentration of 17.5 [+ or -] 2.3 mEq/L, and an adequate respiratory response for the level of chronic metabolic acidosis (mean difference between measured and expected pC[O.sub.2] values, 2.1 mEq/ L).
Metabolic tests were analyzed for inborn error of metabolism due to metabolic acidosis, hypoketotic hypoglycemia, hyperammonemia, and elevated liver enzymes.
The patient was orotracheally intubated due to metabolic acidosis with high anion gap, which was treated using NaHC[O.sub.3].
In metabolic acidosis caused by methanol intake, particularly when pH drops below 7.2, myocardial contractions are suppressed and serious arrhythmias may be observed (6, 7).
Hemodialysis was started two hours after admission due to persistent severe metabolic acidosis and electrolyte imbalance.
The reported results showed a high prevalence of metabolic acidosis and higher partial pressures of oxygen when compared with a healthy population; nevertheless, the conditions of the dialytic treatment were different from those of today, since the standard hemodialysis solution contained 36.6 mmol/L of acetate and high-flux; high-efficiency filters were not available [8].
However, bicarbonate treatment is widely used to stabilise metabolic acidosis in cases of metformin poisoning as described in the literature.
Based on Table 2, metabolic acidosis was first managed with fluid replacement and sodium bicarbonate while searching for possible causes of lactic acidosis.
Malnutrition may be related to metabolic acidosis due to increased protein catabolism, decreased protein synthesis, endocrine abnormalities, and inflammation among dialysis patients [37].
These metabolites are responsible for methanol intoxication that can cause metabolic acidosis, blindness, hemodynamic instability, and death (3).