This last step is very slow thus resulting in accumulation of formic acid in the body which leads to life threatening metabolic acidosis
. Another postulated mechanism is the low hepatic levels of these enzymes in humans leading to methanol intoxication.
An integrative view of findings at the start of the first dialysis of the week showed slight acidemia (mean pH 7.32 [+ or -] 0.05), mean bicarbonate concentration of 17.5 [+ or -] 2.3 mEq/L, and an adequate respiratory response for the level of chronic metabolic acidosis
(mean difference between measured and expected pC[O.sub.2] values, 2.1 mEq/ L).
Metabolic tests were analyzed for inborn error of metabolism due to metabolic acidosis
, hypoketotic hypoglycemia, hyperammonemia, and elevated liver enzymes.
in pregnancy may be life-threatening to both the mother and the fetus.
The patient was orotracheally intubated due to metabolic acidosis
with high anion gap, which was treated using NaHC[O.sub.3].
In metabolic acidosis
caused by methanol intake, particularly when pH drops below 7.2, myocardial contractions are suppressed and serious arrhythmias may be observed (6, 7).
Hemodialysis was started two hours after admission due to persistent severe metabolic acidosis
and electrolyte imbalance.
The reported results showed a high prevalence of metabolic acidosis
and higher partial pressures of oxygen when compared with a healthy population; nevertheless, the conditions of the dialytic treatment were different from those of today, since the standard hemodialysis solution contained 36.6 mmol/L of acetate and high-flux; high-efficiency filters were not available .
However, bicarbonate treatment is widely used to stabilise metabolic acidosis
in cases of metformin poisoning as described in the literature.
Based on Table 2, metabolic acidosis
was first managed with fluid replacement and sodium bicarbonate while searching for possible causes of lactic acidosis.
Malnutrition may be related to metabolic acidosis
due to increased protein catabolism, decreased protein synthesis, endocrine abnormalities, and inflammation among dialysis patients .
These metabolites are responsible for methanol intoxication that can cause metabolic acidosis
, blindness, hemodynamic instability, and death (3).