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A condition of decreased alkali reserve of the blood and other body fluids.



a change in the acid-alkaline balance of the organism as a result of insufficient removal and oxidation of organic acids (for example, beta-hydroxybutyric acid). Usually these products are rapidly removed from the body. In febrile diseases, intestinal disorders, pregnancy, starvation, and such, they are retained in the body; this is manifested in mild cases by the appearance of acetoacetic acid and acetone in the urine (so-called ketonuria). In severe cases (for example, diabetes mellitus) it may lead to coma. Treatment consists of removal of the cause of acidosis (for example, by administering insulin in case of diabetes); there is also symptomatic treatment—soda and an abundance of fluids taken internally.

References in periodicals archive ?
After three years, consuming either fruits and vegetables or the oral medication reduced a marker of metabolic acidosis and preserved kidney function to similar extents.
4,12) It causes severe and intractable secretory diarrhea (150-300 ml/kg/day) that usually starts shortly after birth and persists despite total bowel rest, (1,2,4,8,13) resulting in severe dehydration and profound metabolic acidosis.
A study in children with CRF showed that common presentations were growth failure, metabolic acidosis and hypertension17.
Methanol poisoning has a high mortality and morbidity rate in our setting despite advanced treatment options likely due to late presentation and degree of metabolic acidosis.
Eventually, an imbalanced state develops called metabolic acidosis, which is commonly associated with chronic kidney disease.
However, in your chronically ill patients who demonstrate low-grade, chronic metabolic acidosis, loss of glutamine through this pathway can be significant:
On the other hand, every subject experienced metabolic acidosis for 4mM and their [Lac] moved beyond the range for the steady-state.
This report describes a neonatal presentation with congenital anomalies, metabolic acidosis, and hypoketotic hypoglycemia.
In severe NEC (Stage 2 and 3) apnoeic episodes, bradycardia, gross blood in stools, Thrombocytopenia, metabolic acidosis and hyponatremia were noted.
1 mmol/L) suggestive of severe high anion-gap metabolic acidosis with anion gap of 44.
The questions relate to topics like acid-base disturbances, sodium concentration disorders, the utility of urine anion and osmolal gaps, the use of bicarbonate to treat metabolic acidosis, the use phosphorus binders to treat hyperphosphatemia, the interpretation of changes in plasma creatinine, the urine-to-plasma creatinine ratio, acute renal failure vs.