metabolize

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metabolize

[mə′tab·ə‚līz]
(physiology)
To transform by metabolism; to subject to metabolism.
References in periodicals archive ?
Gurbel urged the investigators to report on outcomes analyzed not just by metabolizer status but also by the treatment they received.
Particularly for nebivolol, the bioavailability of orally taken drug is 12% on average in patients with extensive metabolism, in comparison to 96% in poor metabolizers.
Alternative reliable method for cytochrome P450 2D6 poor metabolizers genotyping.
Thus, the carriers of two CYP2C9*3, as well as, alleles with null capacity are predicted to be poor metabolizers (gPMs) and to suffer adverse drug reactions (ADRs) (Yang et al.
PD, Parkinsons disease patients; CT, unaffected subjects; OR, odds ratio; Cl, confidence interval; REF, reference article; NA, not available; SM, slow metabolizer; PM, poor metabolizer.
7), using inverse ratio (Cod + C6G/ Mor + M3G + M6G) in plasma and urine samples has reported the inverse ratio to be 9 (6-16) in ultrafast metabolizers 12 hours after codeine consumption.
There was no significant difference in phenotype concordance when comparing metabolizer status according to activity score versus the AmpliChip package insert recommendations (data not shown).
Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations.
People who break down caffeine rapidly decrease their risk of a heart attack by drinking coffee, while slow caffeine metabolizers dramatically increase their risk
These same reasons may also explain why we discovered only a single poor metabolizer among the 45 patient cohort.
Poor metabolizer genotype status of CYP2C19 is a risk factor for developing gastric cancer in Japanese patients with Helicobacter pylori infection.
Conversely, the extensive metabolizer phenotype corresponds to the standard metabolic activity of an enzyme and in this category, appropriate therapeutic outcome is achieved with standard drug dosages and minimal or absent toxicity.