metabolize

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metabolize

[mə′tab·ə‚līz]
(physiology)
To transform by metabolism; to subject to metabolism.
References in periodicals archive ?
Gurbel suggested, may be the absence of any compelling data proving whether there's any effect on clinical outcomes for switching reduced metabolizers off of clopidogrel or switching good metabolizers onto it.
9) There is concern that hydrocodone use by women who are breastfeeding and are ultrarapid metabolizers may cause increased fetal consumption of hydromorphone resulting in adverse outcomes in the newborn.
5) The maximum daily dose is 36 mg (18 mg, twice daily) in patients receiving strong CYP2D6 inhibitors or who are 2D6 poor metabolizers.
Interestingly, additional pharmacogenetic testing did not explain the occurrence of this side effect, since the patient was found to be extensive metabolizer of beta blocking agents.
Genetic variability of CYP2C19 in a Mexican population: contribution to the knowledge of the inheritance pattern of CYP2C19*17 to develop the ultrarapid metabolizer phenotype.
PD, Parkinsons disease patients; CT, unaffected subjects; OR, odds ratio; Cl, confidence interval; REF, reference article; NA, not available; SM, slow metabolizer; PM, poor metabolizer.
Ultra-rapid metabolizers have very low debrisoquine metabolic ratio among the extensive metabolizer subjects.
The difference between slow and normal metabolizers is how long nicotine stays in the body after quitting.
Oxycodone (found in Percocet and other products), should have much less variability, though there will still be some added risk to fast metabolizers.
For example, a poor metabolizer, unable to metabolize certain medications, is at risk for accumulation of the active parent compound and increased toxicity, or lack of conversion of a prodrug into an active metabolite and decreased efficacy.