The definitive diagnosis of MLD is based on the detection of ARSA gene mutations associated with clinical findings or an increase in urinary sulfatide output, or by demonstration of metachromatic
lipid accumulation in the nerve or peripheral nerves.
The chromatin quality of spermatozoa was determined according to metachromatic
staining of sperm heads with the aid of light microscopy at x1000 magnification.
Comparative Study of Metachromatic
Staining Methods in Assessing the Exfoliative Cell Types During Oestrous Cycle in Sprague-Dawley Laboratory Rats
On May 23, tests showed it was Metachromatic
Leukodystrophy (MLD) meaning the schoolboy could have anything from three to 15 years to live.
Six cases (5.6%) of mast cell tumor were identified through moderate to high cellularity with cytoplasm containing packed metachromatic
Hand-sections were taken as close as possible to the area from which epidermal peels were taken, and then stained with Toluidine Blue, a metachromatic
The portfolio of gene therapy programmes Orchard has acquired includes: Strimvelis, the first autologous ex vivo gene therapy for children with adenosine deaminase severe combined immunodeficiency (ADA-SCID), approved by the EMA in 2016, two late-stage clinical programmes in ongoing registrational studies for metachromatic
leukodystrophy (MLD) and Wiskott Aldrich syndrome (WAS), and one clinical programme for beta thalassaemia.
leukodystrophy is more common than both Krabbe and GAN, but does not commonly show cerebellar involvement until late in the disease.
The second case involved a child with metachromatic
leukodystrophy who was found to have A.
leukodystrophy (MLD) is a genetic disorder caused by the deficiency of the enzyme arylsulfatase A (ARSA) in lipid metabolism [1-3].
Such staining reaction is known as metachromasia, and the dyes exhibiting metachromatic
properties are known as metachromatic
Initially, progenitor cells (blasts) have a high nuclear to cytoplasm ratio, and then gradually acquire granules that can be stained to form metachromatic