metachromatism

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metachromatism

[¦med·ə′krō·mə ‚tiz·əm]
(chemistry)
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The definitive diagnosis of MLD is based on the detection of ARSA gene mutations associated with clinical findings or an increase in urinary sulfatide output, or by demonstration of metachromatic lipid accumulation in the nerve or peripheral nerves.
The chromatin quality of spermatozoa was determined according to metachromatic staining of sperm heads with the aid of light microscopy at x1000 magnification.
Comparative Study of Metachromatic Staining Methods in Assessing the Exfoliative Cell Types During Oestrous Cycle in Sprague-Dawley Laboratory Rats
Six cases (5.6%) of mast cell tumor were identified through moderate to high cellularity with cytoplasm containing packed metachromatic granules.
Hand-sections were taken as close as possible to the area from which epidermal peels were taken, and then stained with Toluidine Blue, a metachromatic stain.
The portfolio of gene therapy programmes Orchard has acquired includes: Strimvelis, the first autologous ex vivo gene therapy for children with adenosine deaminase severe combined immunodeficiency (ADA-SCID), approved by the EMA in 2016, two late-stage clinical programmes in ongoing registrational studies for metachromatic leukodystrophy (MLD) and Wiskott Aldrich syndrome (WAS), and one clinical programme for beta thalassaemia.
Metachromatic leukodystrophy is more common than both Krabbe and GAN, but does not commonly show cerebellar involvement until late in the disease.
The second case involved a child with metachromatic leukodystrophy who was found to have A.
Metachromatic leukodystrophy (MLD) is a genetic disorder caused by the deficiency of the enzyme arylsulfatase A (ARSA) in lipid metabolism [1-3].
Such staining reaction is known as metachromasia, and the dyes exhibiting metachromatic properties are known as metachromatic dyes.
Initially, progenitor cells (blasts) have a high nuclear to cytoplasm ratio, and then gradually acquire granules that can be stained to form metachromatic blasts.