(Forge), a biotechnology company developing novel medicines targeting metalloenzymes
, announced today that the United States Patent and Trademark Office (USPTO) has issued a notice of allowance for its patent application directed to compositions of matter and methods of use of certain 'non-hydroxamate' inhibitors of LpxC for the treatment of Gram-negative bacterial infections.
According to Forge, its BLACKSMITH comprises a deep knowledge of metalloenzymes
, bioinorganic and medicinal chemistry know-how and a focused library of proprietary metal-binding fragment pharmacophores (MBPs) that provide selective and diverse starting points for novel inhibitors.
The element functions mainly as a divalent cation in metalloenzymes
and among these functions is the linkage of these enzymes to their corresponding substrates.
Viamet Pharmaceuticals discovers and develops breakthrough therapies based its metalloenzyme
chemistry and biology.
As has been well described, a higher intracellular concentration of ROS is also connected with the release of other biometals from their binding to metalloenzymes
Although it has been shown that the metalloenzyme
carbonic anhydrase (CA) is involved in molluscan and cnidarian biomineralization processes, no study has examined the expression of biomineralization genes in serpulids (Miyamoto et al., 1996; Moya et al., 2008).
SAHA has the ability to inhibit HDAC, and it could interact with the HDAC metalloenzyme
Mao, "Insights into metalloenzyme
microenvironments: biomimetic metal complexes with a functional second coordination sphere," Chemical Society Reviews, vol.
Most of the amylases are metalloenzyme
requiring [Ca.sup.+2] for their activity, structural integrity, and stabilization [12-14].
a-Toxin, a zinc metalloenzyme
with phospholipase, sphingomyelinase, and hemolytic activities, is produced by C.
This has been explained by the mobili- zation of serum zinc to the area of tissue injury to participate in the reparative process.17 Some other workers explained the fall of zinc in blood on the basis of transportation of zinc into necrosed myocar-dium to take part in the synthesis of lactic dehydro- genase that is a metalloenzyme
.18 Another scientist explained this on the basis of the humoral factor known as the leukocytic endogenous mediator released from polymorphonuclear leukocytes in the presence of myocardial necrosis.19
Zinc is metalloenzyme
which forms Zn-enzyme complex.