metalloprotein

(redirected from metalloenzyme)
Also found in: Dictionary, Medical.

metalloprotein

[mə‚tal·ō′prō‚tēn]
(biochemistry)
A protein enzyme containing a metallic atom as an inherent portion of its molecule.
Mentioned in ?
References in periodicals archive ?
(Forge), a biotechnology company developing novel medicines targeting metalloenzymes, announced today that the United States Patent and Trademark Office (USPTO) has issued a notice of allowance for its patent application directed to compositions of matter and methods of use of certain 'non-hydroxamate' inhibitors of LpxC for the treatment of Gram-negative bacterial infections.
Forge Therapeutics receives notice of allowance from U.S. patent and trademark office covering novel chemistry targeting LpxC
According to Forge, its BLACKSMITH comprises a deep knowledge of metalloenzymes, bioinorganic and medicinal chemistry know-how and a focused library of proprietary metal-binding fragment pharmacophores (MBPs) that provide selective and diverse starting points for novel inhibitors.
Forge & Basilea partner to discover and develop novel antibiotics
The element functions mainly as a divalent cation in metalloenzymes and among these functions is the linkage of these enzymes to their corresponding substrates.
ZINC METALLOENZYMES IN PLANTS/METALOENZIMAS DE ZINC EN PLANTAS/METALOENZIMAS DE ZINCO EM PLANTAS
Viamet Pharmaceuticals discovers and develops breakthrough therapies based its metalloenzyme chemistry and biology.
NovaQuest Capital to Acquire Viamet Pharmaceuticals to Accelerate Development of VT-1161
As has been well described, a higher intracellular concentration of ROS is also connected with the release of other biometals from their binding to metalloenzymes (Table 2).
The Central Role of Biometals Maintains Oxidative Balance in the Context of Metabolic and Neurodegenerative Disorders
Although it has been shown that the metalloenzyme carbonic anhydrase (CA) is involved in molluscan and cnidarian biomineralization processes, no study has examined the expression of biomineralization genes in serpulids (Miyamoto et al., 1996; Moya et al., 2008).
Expression and localization of carbonic anhydrase genes in the serpulid polychaete Hydroides elegans
SAHA has the ability to inhibit HDAC, and it could interact with the HDAC metalloenzyme site [31].
Utilization of boron compounds for the modification of suberoyl anilide hydroxamic acid as inhibitor of histone deacetylase class II Homo sapiens
Mao, "Insights into metalloenzyme microenvironments: biomimetic metal complexes with a functional second coordination sphere," Chemical Society Reviews, vol.
Macrocyclic assembly: a dive into the pecking order and applied aspects of multitalented metallomacrocycles
Most of the amylases are metalloenzyme requiring [Ca.sup.+2] for their activity, structural integrity, and stabilization [12-14].
Optimization of amylase production from B. amyloliquefaciens (MTCC 1270) using solid state fermentation
a-Toxin, a zinc metalloenzyme with phospholipase, sphingomyelinase, and hemolytic activities, is produced by C.
Effect of Bacillus subtilis-based direct-fed microbials on immune status in broiler chickens raised on fresh or used litter
This has been explained by the mobili- zation of serum zinc to the area of tissue injury to participate in the reparative process.17 Some other workers explained the fall of zinc in blood on the basis of transportation of zinc into necrosed myocar-dium to take part in the synthesis of lactic dehydro- genase that is a metalloenzyme.18 Another scientist explained this on the basis of the humoral factor known as the leukocytic endogenous mediator released from polymorphonuclear leukocytes in the presence of myocardial necrosis.19
A STUDY OF SERUM ZINC LEVELS AMONG PATIENTS OF CORONARY ARTERY DISEASE CONDUCTED IN A TERTIARY CARE HOSPITAL
Zinc is metalloenzyme which forms Zn-enzyme complex.
Study of micro elements in diabetic retinopathy

Encyclopedia browser ?
Full browser ?