metanephrine


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Related to metanephrine: pheochromocytoma, Catecholamines

metanephrine

[‚med·ə′ne‚frən]
(biochemistry)
An inactive metabolite of epinephrine (3-O-methylepinephrine) that is excreted in the urine; it is recovered and measured as a test for pheochromocytoma.
References in periodicals archive ?
Labetalol displayed a small early eluting peak when monitoring the metanephrine qualifier transition m/z 180 [right arrow] 165 (Fig.
The preoperative diagnosis of pheochromocytoma is supported by elevated levels of urine and blood catecholamines and their metabolites, metanephrine and vanillyl mandelic acid (VMA).
With improved analytical sensitivity of modern LC-ECD and LC-MS/MS instruments, it has become possible to measure urine free metanephrines (16, 24), which also provide improved diagnosis of PPGLs compared to catecholamines and VMA (25).
As in nonpregnant women, the diagnosis is usually based upon the results of 24-hour urinary fractionated metanephrines (metanephrine and normetanephrine) and catecholamines (dopamine, norepinephrine, and epinephrine) and plasma fractionated metanephrines [6].
[6] Nonstandard abbreviations: PMets, plasma metanephrines; NMN, normetanephrine; MN, metanephrine; UMets, urine MNs; PCC, pheochromocytoma.
Large paragangliomas with low or normal metanephrine concentrations have been described in patients with SDHB [succinate dehydrogenase complex, subunit B, iron sulfur (Ip)] mutations, which reflects the typically immature phenotypic features of these tumors.
Plasma free and urinary fractionated metanephrines are regarded as the first-line tests in screening for PPGL.
Although the total metanephrine concentration has been used in the past, the current recommendation is for split metanephrines (MN and NMN) to be reported, because this approach enhances the sensitivity of the test.
Serum norepinephrine, epinephrine, metanephrine and normetanephrine levels studied for hypertension aetiology were within normal limits.
For lipids, metanephrine, normetanephrine, or hemoglobin A1c, there were no differences between the groups.
(7,10) Furthermore, PGLs with germline mutations in SDHB and SDHD are also typically negative for epinephrine and metanephrine secretions.