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1. Pathol the spreading of a disease, esp cancer cells, from one part of the body to another
2. a rare word for metabolism



a secondary pathological focus arising from the transfer of a pathogenic principle (tumor cells, infectious agent) from the primary site of affection by the lymph or blood.

In the modern view, the term “metastasis” generally applies to the spread (dissemination) of malignant tumor cells; the spread of an infectious principle is usually described by the term “metastatic infectious focus.”

Benign tumors are also known to metastasize, and the capacity to do so is inherent in normal cells of various origin (in placental villi, adipose and hematopoietic bone-marrow cells). A distinctive feature of metastasizing tumor cells is the uncontrollable growth of the metastasis, relating it to primary foci of malignant growth. Metastatic tumor nodes retain other properties of primary tumors as well, such as microstructural features and the capacity to form the same products; however, metastatic nodes often have a more primitive structure and consist of functionally less mature cells than do the original tumors.

When tumor cells spread chiefly through the lymphatic vessels, metastases generally appear in the lymph nodes closest to the primary site. Although much research has been devoted to the routes and anatomical patterns of lymphogenous metastasis, the biological patterns of formation of lymphogenous metastases remain obscure. The mechanisms of hematogenous metastasis (to the lungs, liver, bones, and other viscera) are better understood. Four stages in the development of hematogenous metastasis are distinguished: (1) the detachment of cells from the primary tumor node and their penetration of the blood through the vascular wall; (2) the circulation of the tumor cells in the blood; (3) the attachment of the cells to the vascular wall and the start of intravascular growth; and (4) the rupture of the vascular wall by the tumorous masses and the subsequent growth of the metastasis into the tissue of the affected organ. The presence of metastasis indicates that a tumorous process has shifted from a local growth phase to a phase of generalization. A distinction is made between solitary metastasis, which generally can be removed surgically, and multiple metastases, which require combined treatment using radiation and chemotherapy.



Transfer of the causal agent (cell or microorganism) of a disease from a primary focus to a distant one through the blood or lymphatic vessels.
A transition of an electron or nucleon from one bound state to another in an atom or molecule, or the capture of an electron by a nucleus.
References in periodicals archive ?
The Metastatic Breast Cancer Alliance, the largest breast cancer coalition of its kind, represents more than 35 cancer organizations working together to improve the length and quality of life for people living with metastatic breast cancer; advance progress in scientific research; and build the public's general understanding of the disease and how a metastatic diagnosis differs from early stage breast cancer.
Approximately half of all patients have already developed a cervical metastasis at the time of presentation, and approximately two-thirds die of widespread metastatic disease (survival range: 1 to 26 mo).
Moreover, his data suggest that by preventing potentially metastatic cells from embedding -- and hiding out -- in basement membranes, the new drugs might increase the cancer-killing efficacy of more traditional anticancer drugs.
A review of the Metastatic Hormone Refractory Prostate Cancer products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
But, metastatic breast cancer is still largely misunderstood.
Metastatic renal cell carcinoma to the thyroid gland: A clinicopathologic study of 36 cases.
Ideally, the presence or absence of the NM23 gene could help physicians gauge the metastatic potential of the cancer.
Devise corrective measures for pipeline projects by understanding Metastatic Prostate Cancer pipeline depth and focus of Metastatic Prostate Cancer therapeutics.
For more information about metastatic breast cancer and resources that support these women and their loved ones, please visit mbcInfoCenter.
Our superficial search of the MEDLINE database dating from 1966 turned up only a handful of previously reported cases of a metastatic germ cell tumor that initially manifested as a neck mass.
Devise corrective measures for pipeline projects by understanding Metastatic Hepatocellular Carcinoma (HCC) pipeline depth and focus of Indication therapeutics.
23, 2014 /PRNewswire/ -- More than 173,000 women in the United States are living with metastatic breast cancer and each has a story to tell.