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1. Pathol the spreading of a disease, esp cancer cells, from one part of the body to another
2. a rare word for metabolism



a secondary pathological focus arising from the transfer of a pathogenic principle (tumor cells, infectious agent) from the primary site of affection by the lymph or blood.

In the modern view, the term “metastasis” generally applies to the spread (dissemination) of malignant tumor cells; the spread of an infectious principle is usually described by the term “metastatic infectious focus.”

Benign tumors are also known to metastasize, and the capacity to do so is inherent in normal cells of various origin (in placental villi, adipose and hematopoietic bone-marrow cells). A distinctive feature of metastasizing tumor cells is the uncontrollable growth of the metastasis, relating it to primary foci of malignant growth. Metastatic tumor nodes retain other properties of primary tumors as well, such as microstructural features and the capacity to form the same products; however, metastatic nodes often have a more primitive structure and consist of functionally less mature cells than do the original tumors.

When tumor cells spread chiefly through the lymphatic vessels, metastases generally appear in the lymph nodes closest to the primary site. Although much research has been devoted to the routes and anatomical patterns of lymphogenous metastasis, the biological patterns of formation of lymphogenous metastases remain obscure. The mechanisms of hematogenous metastasis (to the lungs, liver, bones, and other viscera) are better understood. Four stages in the development of hematogenous metastasis are distinguished: (1) the detachment of cells from the primary tumor node and their penetration of the blood through the vascular wall; (2) the circulation of the tumor cells in the blood; (3) the attachment of the cells to the vascular wall and the start of intravascular growth; and (4) the rupture of the vascular wall by the tumorous masses and the subsequent growth of the metastasis into the tissue of the affected organ. The presence of metastasis indicates that a tumorous process has shifted from a local growth phase to a phase of generalization. A distinction is made between solitary metastasis, which generally can be removed surgically, and multiple metastases, which require combined treatment using radiation and chemotherapy.



Transfer of the causal agent (cell or microorganism) of a disease from a primary focus to a distant one through the blood or lymphatic vessels.
A transition of an electron or nucleon from one bound state to another in an atom or molecule, or the capture of an electron by a nucleus.
References in periodicals archive ?
Integrative clinical genomics of metastatic cancer. Nature 2017;548:297-303.
The Health Authority - Abu Dhabi (Haad) announced the death of a 35-year old Nigerian woman, who was travelling from Nigeria to India for medical treatment of advanced metastatic cancer. During the transit phase at Abu Dhabi International Airport, the patient's health deteriorated and despite prompt medical assistance, she could not be successfully resuscitated, Haad said in a statement.
B should have performed pelvic lymphadenectomy at hysterectomy; a lymphadenectomy would have accurately staged metastatic cancer.
Currently, NGS is being used in metastatic cancer to "systematically catalogue" cancer genomes to assess both common and rare mutations, in the hope of identifying targeted treatment regimens or to enroll patients in clinical trials.
* A review of the Metastatic Cancer products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
"The medical prognosis at this point is bleak and this leads many metastatic cancer patients to feel hopeless and left out.
Still, metastatic cancer is the most dangers kind, with fewer than one-third of women surviving at least five years after diagnosis, Johnson's team wrote.
Participants were 1 018 patients with locally advanced or metastatic cancer, no longer being treated for cancer, and recently referred to palliative care services.
Early palliative care can improve quality of life, decrease depressive symptoms, and prolong life in patients with metastatic cancer. (1)
Patients with recurrent or metastatic cancer of the head and neck given a combination of Alimta and cisplatin, a platinum-based chemotherapy, showed a median overall survival of 7.3 months compared with 6.3 months for those on cisplatin alone.
A mother of two, she died of metastatic cancer. An annual poetry prize is given in her honor.
In patients with metastatic cancer, CTCs were detected in 23 of 36 (64%) cases and declined after the initiation of effective therapy.