Methemoglobinemia

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methemoglobinemia

[¦met‚hē·mə·glō·bə′nē·mē·ə]
(medicine)
The presence of methemoglobin in the blood.

Methemoglobinemia

 

the appearance of methemoglobin in the blood as a result of the toxic effect of various chemical substances (nitrates and nitrites, aniline, pyridine) that are capable of converting hemoglobin to methemoglobin (MtHb) upon entering the body through the skin, digestive tract, or lungs. With considerable methemoglobinemia, oxygen starvation, or hypoxia, may result. Methemoglobin may be excreted with the urine (methemoglobinuria); this is sometimes damaging to the kidneys. Methemoglobinemia is treated with antidotes (methylene blue, ascorbic acid) and oxygen therapy.

References in periodicals archive ?
A literature search did not demonstrate any study that has identified the effect of arterial hypoxaemia in methaemoglobinaemia patients.
Drugs causing methaemoglobinaemia are acetanilide, alloxan, aniline, arsine, benzene derivatives, bivalent copper, bismuth, bupivacaine, chorates, chloroquine, chromates, dapsone, dimethyl sulfoxide, dinitrophenol, exhaust fumes, ferricyanide, flutamide, hydroxylamine, lidocaine, metoclopramide, naphthalene, nitrates, nitrofuran, nitroglycerin, sodium nitroprusside, paraquet, phenacetin, phenol, phenytoin, rifampin, sulphasalazine and sulphonamides
High concentrations of nitrate in drinking water may impact the health system in human population as such that it can lead to various blood defects such as methaemoglobinaemia [7].
Rogan, "Familial idiopathic methaemoglobinaemia: treatment with ascorbic acid," British Medical Journal, vol.
[20] Methaemoglobinaemia and increased nitrogen dioxide are known side-effects that occur more frequently at dosages greater than 20 ppm.
Drugs may cause haemolytic anaemia (quinidine and penicillin); methaemoglobinaemia (nitrites and nitrates); sulfhaemoglobinaemia (dapsone and sulfonamides); and acute or chronic fibrosis (nitrofurantoin or amiodarone).
Methaemoglobinaemia following treatment dispensed by witch doctors.
The reduced oxygen transport becomes clinically manifest when methaemoglobin concentrations reach to 10% or more of normal Hb concentrations; the condition, called methaemoglobinaemia, causes cyanosis and, at higher concentrations, asphyxia (WHO, 2004).
However, more recent research suggests that methaemoglobinaemia in infants may have been caused by bacteria associated with the pollution of wells by animal or human excrement, rather than nitrate per se (Hatch et al.
Recessive congenital methaemoglobinaemia: cytochrome b(5) reductase deficiency.
Rajabi, "Fatal reactions and methaemoglobinaemia after silver nitrate irrigation of hydatid cyst," Surgical Practice, vol.