methotrexate


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methotrexate

methotrexate, drug used in halting the growth of actively proliferating tissues. Introduced in the 1950s, it is used in the treatment of leukemia, psoriasis, and non-Hodgkin's lymphoma. By binding to an enzyme that controls the metabolism of folic acid, methotrexate interferes with synthesis of nucleic acids and therefore with tissue cell reproduction. Because of its immunosuppressive qualities, it is also used in the treatment of rheumatoid arthritis.
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methotrexate

[‚meth·ə′trek‚sāt]
(pharmacology)
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
In addition, to help patients follow the once-weekly dosing, methotrexate tablets will be provided in blister packs and not in bottles (or tubes).
This trial will assess whether the combination of Krystexxa with methotrexate can enhance the demonstrated response rate of Krystexxa, will confirm the safety and tolerability and provide information on the pharmacokinetics of the combined use.
Randomization assigned patients to receive either 15-20 mg methotrexate orally once a week or placebo.
"The most common serious adverse events were infections and infestations, which occurred in 1.1% of patients in the methotrexate monotherapy arm, 2.8% of patients in the etanercept monotherapy arm, and 2.5% of patients in the combination therapy arm," they wrote.
The use of methotrexate in the medical treatment of ectopic pregnancy was defined by Stovval TG et al.3 in 1989.
Outcomes related to methotrexate dose and route of administration in patients with rheumatoid arthritis: a systematic literature review.
Hemodialysis and peritoneal dialysis were compared by Diskin et al when tackling methotrexate toxicity in a renal failure patient who was put on peritoneal dialysis before the episode of methotrexate toxicity.
"At week 16, the 26% difference between adalimumab 0.8 mg/kg and methotrexate in the proportion of patients who achieved PASI 75 was significant and clinically relevant," Dr.
Methotrexate is currently considered the first-line disease-modifying antirheumatic drugs (DMARDs) [1, 2].
Conclusion: Methotrexate is better option for treatment of moderate to severe plaque psoriasis than acitretin.
Contraindications to Methotrexate Absolute Contraindications
As for dosage, "I do think we can use less methotrexate in combination" with a biologic for psoriasis than when using methotrexate alone, he noted.