In addition, to help patients follow the once-weekly dosing, methotrexate
tablets will be provided in blister packs and not in bottles (or tubes).
This trial will assess whether the combination of Krystexxa with methotrexate
can enhance the demonstrated response rate of Krystexxa, will confirm the safety and tolerability and provide information on the pharmacokinetics of the combined use.
Randomization assigned patients to receive either 15-20 mg methotrexate
orally once a week or placebo.
"The most common serious adverse events were infections and infestations, which occurred in 1.1% of patients in the methotrexate
monotherapy arm, 2.8% of patients in the etanercept monotherapy arm, and 2.5% of patients in the combination therapy arm," they wrote.
The use of methotrexate
in the medical treatment of ectopic pregnancy was defined by Stovval TG et al.3 in 1989.
Outcomes related to methotrexate
dose and route of administration in patients with rheumatoid arthritis: a systematic literature review.
Hemodialysis and peritoneal dialysis were compared by Diskin et al when tackling methotrexate
toxicity in a renal failure patient who was put on peritoneal dialysis before the episode of methotrexate
"At week 16, the 26% difference between adalimumab 0.8 mg/kg and methotrexate
in the proportion of patients who achieved PASI 75 was significant and clinically relevant," Dr.
is currently considered the first-line disease-modifying antirheumatic drugs (DMARDs) [1, 2].
is better option for treatment of moderate to severe plaque psoriasis than acitretin.
Contraindications to Methotrexate
As for dosage, "I do think we can use less methotrexate
in combination" with a biologic for psoriasis than when using methotrexate
alone, he noted.