ADI provisory values for OCPs provided by the WHO in 2009 are 0.6 [micro]g x [kg.sup.-1] [day.sup.1] for HCB, 5 [micro]g x [kg.sup.-1] [day.sup.1] for [summation]-HCH, 0.5 [micro]g x [kg.sup.-1] [day.sup.1] for X-chlordane, 10 [micro]g x [kg.sup.-1] [day.sup.-1] for [summation]-DDX, 0.1 [micro]g x [kg.sup.-1] [day.sup.1] for heptachlor, 10 [micro]g x [kg.sup.-1] [day.sup.1] for methoxychlor
and 0.1 [micro]g x [kg.sup.-1] [day.sup.-1] for Hg.
Other examined OCPs such as chlordane, HCB, and methoxychlor
were detected in 10-60% (see Figure 1).
OCPs detected include [beta]-HCH, [gamma]-HCH, [delta]-HCH, endosulfan sulphate, p,p'-DDT, and methoxychlor
. All others were below the detection limit.
NF/PB, [beta]-naphtoflavone/phenobarbital; AR, androgen receptor; BaP, benzo(a)pyrene; BPA, bisphenol A; CALUX, chemically activated luciferase gene expression; CYP, cytochrome P450; DHT, dihydrotestosterone; DMSO, dimethylsulfoxide; E2, 17[beta] estradiol; EAS, endocrine active substances; [EC.sub.50], half-maximal effective concentration; EDTA, ethylenediaminetetraacetic acid; ERa, estrogen receptor [alpha]; HPTE, 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; [IC.sub.50], half-maximal inhibitory concentration; MC, methoxychlor
; RLU, relative light unit; S9, hepatic 9 000 x G supernatant; STZ, stanozolol
Concentrations of cyfluthrin and methoxychlor
were the same as their MRL and those of fenvalerate and permethrin were close to their MRL, whiles that of chlorpyrifos was lower than its MRL.
Sadly, even after the highly toxic dichlorodiphenyltrichloroethane (DDT) was banned, risks still abound, both because of persistent DDT in the environment and because newer compounds intended to replace DDT (such as methoxychlor
) are turning out to have their own cancer-inducing properties.
An elevation in lipidperoxidation caused by other pesticides in different experiments has also been reported; Methoxychlor
,  endosulfan,  and 2,3,7,8-tetrachlorobenzo-P-dioxin(TCDD),  malathion, and dimethoate.
The best known imprinters from the environmental pollutants are lead, arsenic, cadmium, benzopyrene and various dioxins, furans, polychlorinated biphenyls and pesticides (DDT, DDE, methoxychlor
, chlordecone, parathion, malathion, paraquat, cypermethrin and cyhalothrin).
Kelce, The estrogenic and antiandrogenic pesticide methoxychlor
alters the reproductive tract and behaviour without affecting pituitary size or LH and prolactin secretion in male rats", Toxicology and Industrial Health, 15, 37e47, (1999a)
Washington, July 25 ( ANI ): A new study has revealed that ancestral exposures to the pesticide methoxychlor
may lead to kidney disease, ovarian disease and obesity in future generations.
TEHRAN (FNA)- Researchers said ancestral exposures to the pesticide methoxychlor
may lead to adult onset kidney disease, ovarian disease and obesity in future generations.
Gaido (1998).Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor
in HepG2 human hepatoma cells.